|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Samples were analysed using bead-based multiplex assays for IgG antibodies for six Plasmodium antigens: four human malaria species-specific merozoite surface protein-1 19kD antigens (MSP-1) and Apical Membrane Antigen-1 (AMA-1) for Plasmodium falciparum and Plasmodium vivax.
|
31331340 |
2019 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
However infants from CAIG (n = 53) had significantly higher AMA1-, MSP2-FC27-, MSP3-specific IgG1 and AMA1-, MSP1-, MSP2-FC27-, MSP3 and GLURP-R2-specific IgG3 than those from NCIG (n = 183).
|
31185998 |
2019 |
|
Malaria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Antibody levels against MSP1 19kD, MSP2, schizont extract, and IE variant surface antigens were significantly higher in children who had documented episodes of malaria than in children who did not.
|
30658632 |
2019 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The merozoite surface protein-1 (MSP-1) gene encodes for a leading malaria vaccine candidate antigen.
|
30518419 |
2018 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
N-terminal of MSP-1 gene were amplified from 126 clinical samples collected from imported cases of malaria in migrant workers returning to Jiangsu Province from Africa using a conventional polymerase chain reaction (PCR) assay.
|
30446012 |
2018 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have developed an experimental vaccine candidate (PyCMP) based on pre-erythrocytic (CSP) and erythrocytic (MSP1) stage antigens derived from the rodent malaria parasite P. yoelii.
|
28483199 |
2017 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggest that MSP-1, especially the partially conserved subunit MSP-1<sub>83</sub>, is a major target of opsonizing antibodies acquired during natural exposure to malaria.
|
28877929 |
2017 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we cloned and characterized the full-unit <i>Plasmodium yoelii</i> genes encoding merozoite surface protein 1 (MSP1), circumsporozoite protein (CSP), and Duffy-binding protein (DBP), each of which can be applied for investigations to obtain potent protective vaccines in the rodent malaria model, due to their specific expression patterns during the parasite life cycle.
|
28719950 |
2017 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conducted a genome-wide association study (GWAS) of antibody responses directed to three Plasmodium falciparum vaccine candidate antigens (MSP1, MSP2 and GLURP) previously associated with different patterns of protection against malaria infection in Senegalese children.
|
26741287 |
2016 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The predominant MSP1 allelic families were MAD20 for uncomplicated malaria and RO33 for severe malaria.
|
27350250 |
2016 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The multiplicities of infection (MOI) were low and comparable for msp-1 (1.19 vs 1.22) and msp-2 (1.11 vs 1.10), respectively between malaria and arbovirus-malaria groups.
|
26969623 |
2016 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
α-Thalassaemia trait is associated with antibody prevalence against malaria antigens AMA-1 and MSP-1.
|
25604491 |
2015 |
|
Malaria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Detection of human malaria using recombinant Plasmodium knowlesi merozoire surface protein-1 (MSP-1₁₉) expressed in Escherichia coli.
|
25812552 |
2015 |
|
Malaria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
DNA was extracted and typed for 202 Single Nucleotide Polymorphisms with known associations to malaria or antibody production, and antibody levels to four clinical grade malarial antigens [AMA1, MSP1, MSP2, and (NANP)4] plus total IgE were measured by ELISA techniques.
|
26314886 |
2015 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest an essential role of the MSP1-GPA-band 3 complex during the initial adhesion phase of malaria parasite invasion of RBCs.
|
25778531 |
2015 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we assess serum antibody responses against both the MSP1 and AMA1 antigens following i) ChAd63-MVA immunization, ii) immunization and CHMI, and iii) primary malaria exposure in the context of CHMI in unimmunized control volunteers.
|
25254500 |
2014 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analysis of human B-cell responses following ChAd63-MVA MSP1 and AMA1 immunization and controlled malaria infection.
|
24303947 |
2014 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
For example, in the human malaria parasite Plasmodium falciparum, genotyping of the merozoite surface protein (MSP1/2) genes is a standard method for assessing MOI, despite the apparent problem of underestimation.
|
24443379 |
2014 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inclusion of multiple Ag variants in subunit vaccine candidates is one strategy that has aimed to overcome this problem for the leading blood-stage malaria vaccine targets, that is, merozoite surface protein 1 (MSP1) and apical membrane Ag 1 (AMA1).
|
23293353 |
2013 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to determine the genetic diversity of Plasmodium falciparum by analyzing the polymorphism of the msp-1 and msp-2 genes and the multiplicity of infection in children with uncomplicated malaria in southern Benin.
|
24135216 |
2013 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Severity of malaria was not linked to the predominance of any particular msp1 or msp2 allelic types, independent of methods used for genotyping.
|
23408340 |
2013 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Effect of malaria transmission reduction by insecticide-treated bed nets (ITNs) on the genetic diversity of Plasmodium falciparum merozoite surface protein (MSP-1) and circumsporozoite (CSP) in western Kenya.
|
23978002 |
2013 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The blood-stage malaria vaccines were administered alone, or together (MSP1+AMA1), or with a pre-erythrocytic malaria vaccine candidate (MSP1+ME-TRAP).
|
23089736 |
2012 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
A significant increase in antibodies against Plasmodium falciparum antigens AMA1, MSP2, NANP and Plasmodium vivax antigen MSP1 in individuals with past history of malaria were observed when compared to those who did not.
|
22905743 |
2012 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, we suggest a potential regulatory role of the HLA-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria.
|
22107686 |
2012 |