|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The delineation of the role of MSP-1 in parasite invasion is an important component of the development of a multi-subunit malaria vaccine, and this study identifies a candidate antigen in this context.
|
10802320 |
2000 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The genes encoding the polymorphic merozoite surface proteins 1 (msp-1) and 2 (msp-2) and the dihydrofolate reductase (dhfr) of malaria parasites have been extensively used as markers to investigate the genetic diversity and the population structure of P. falciparum.
|
18571110 |
2008 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Data from this study can assist in making decisions for further clinical development of MSP1-based candidates, and this process sets a precedent for future comparisons of malaria vaccine candidates.
|
19038302 |
2009 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The polymorphic merozoite surface protein (MSP-1) of Plasmodium falciparum is a major asexual blood-stage malaria vaccine candidate.
|
10531247 |
1999 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
However infants from CAIG (n = 53) had significantly higher AMA1-, MSP2-FC27-, MSP3-specific IgG1 and AMA1-, MSP1-, MSP2-FC27-, MSP3 and GLURP-R2-specific IgG3 than those from NCIG (n = 183).
|
31185998 |
2019 |
|
Malaria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Detection of human malaria using recombinant Plasmodium knowlesi merozoire surface protein-1 (MSP-1₁₉) expressed in Escherichia coli.
|
25812552 |
2015 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Predicted and observed alleles of Plasmodium falciparum merozoite surface protein-1 (MSP-1), a potential malaria vaccine antigen.
|
9657329 |
1998 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Merozoite surface protein-1 (MSP-1) of Plasmodium falciparum is a malaria vaccine candidate Ag.
|
9647243 |
1998 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The merozoite surface protein MSP1, which is one of the most promising candidates for a malaria vaccine directed against erythrocytic stages, has been shown to be polymorphic in different malarial species.
|
8454028 |
1993 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Merozoite surface protein-1 (MSP-1) and MSP-2 of Plasmodium falciparum are potential vaccine candidate antigens for malaria vaccine development.
|
20478015 |
2010 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The polymorphic merozoite surface protein 1 (MSP-1) of Plasmodium falciparum is a major asexual blood stage malaria vaccine candidate antigen.
|
15381807 |
2004 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report the first trial of candidate malaria vaccine antigen FMP1, a 42kDa fragment from the C-terminus of merozoite surface protein-1 (MSP-1) from the 3D7 strain of Plasmodium falciparum, in an endemic area.
|
16388879 |
2007 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
A successful anti-blood stage malaria vaccine trial based on a leading vaccine candidate, the major merozoite surface antigen-1 (MSP1), is reported here.
|
9529073 |
1998 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genotyping of Plasmodium falciparum based on PCR amplification of the polymorphic genes encoding the merozoite surface proteins 1 and 2 (msp1 and msp2) is well established in the field of malaria research to determine the number and types of concurrent clones in an infection.
|
19386138 |
2009 |
|
Malaria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Antibody levels against MSP1 19kD, MSP2, schizont extract, and IE variant surface antigens were significantly higher in children who had documented episodes of malaria than in children who did not.
|
30658632 |
2019 |
|
Malaria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
DNA was extracted and typed for 202 Single Nucleotide Polymorphisms with known associations to malaria or antibody production, and antibody levels to four clinical grade malarial antigens [AMA1, MSP1, MSP2, and (NANP)4] plus total IgE were measured by ELISA techniques.
|
26314886 |
2015 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of 14 MSP-1(19) haplotypes were compared over the course of the malaria transmission season for all three years, in three age groups, and in consecutive infections within individuals.
|
17355170 |
2007 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we cloned and characterized the full-unit <i>Plasmodium yoelii</i> genes encoding merozoite surface protein 1 (MSP1), circumsporozoite protein (CSP), and Duffy-binding protein (DBP), each of which can be applied for investigations to obtain potent protective vaccines in the rodent malaria model, due to their specific expression patterns during the parasite life cycle.
|
28719950 |
2017 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The recombinant apical membrane antigen 1 (AMA-1) and 19-kDa fragment of merozoite surface protein (MSP-1(19)) are the lead candidates for inclusion in a vaccine against blood stages of malaria due to encouraging protective studies in humans and animals.
|
18242795 |
2008 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results showed that women who were antibody negative for MSP1-19 were at a higher risk of having placental malaria than women with antibodies (P < 0.007).
|
14977967 |
2004 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since P. vivax accounts for >50% of malaria cases in India and in Colombia, it is essential to know the Pvmsp-1 gene variability in these two countries to sustain it as a vaccine candidate.
|
15003129 |
2004 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest an essential role of the MSP1-GPA-band 3 complex during the initial adhesion phase of malaria parasite invasion of RBCs.
|
25778531 |
2015 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, although neither the prevalence nor the concentration of total anti-MSP-1(19) antibodies was associated with resistance to malaria in African children, significant associations were observed between antibody fine specificity and subsequent risk of infection and high-density parasitemia during a follow-up period.
|
14977962 |
2004 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Effect of malaria transmission reduction by insecticide-treated bed nets (ITNs) on the genetic diversity of Plasmodium falciparum merozoite surface protein (MSP-1) and circumsporozoite (CSP) in western Kenya.
|
23978002 |
2013 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The 19-kDa C-terminal region of merozoite surface protein 1 (MSP1(19)), a major blood stage malaria vaccine candidate, is the target of cellular and humoral immune responses in humans naturally infected with Plasmodium falciparum.
|
22059995 |
2011 |