Disease: Acquired long QT syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2732979
Disease: Acquired long QT syndrome
Acquired long QT syndrome 		0.020 Biomarker disease BEFREE Our findings suggest that KCR1 genetic variations that diminish the ability of KCR1 to protect KCNH2 from inhibition by commonly used therapeutic agents constitute a risk factor for the aLQTS. 20950623 2011
CUI: C2732979
Disease: Acquired long QT syndrome
Acquired long QT syndrome 		0.020 GeneticVariation disease BEFREE Examination of the human KCR1 sequence in patients with drug-induced cardiac repolarization defects revealed a sequence variation (the substitution of isoleucine 447 by valine, I447V) that occurs at a reduced frequency (1.1%) relative to a matched control population (7.0%), suggesting that I447V may be an allele for reduced aLQTS susceptibility. 15280551 2004