PPFIBP2, PPFIA binding protein 2, 8495

N. diseases: 13; N. variants: 4
Disease: Prostate carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.120 GeneticVariation disease GWASCAT Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. 29892016 2018
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.120 GeneticVariation disease BEFREE The PPFIBP2 loss-of-function mutation carrier rate in lethal PCa cases was also higher than in 33 370 non-Finnish European individuals from the Exome Aggregation Consortium (ExAC) (carrier rate of 0.17%, P = 1.92 × 10<sup>-5</sup> ) and in 498 men with localized PCa from The Cancer Genome Atlas cohort (TCGA) cohort (carrier rate of 0%, P = 0.0058). 30043417 2018
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.120 GeneticVariation disease BEFREE We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12791447, P=3.59 × 10(-8); PPFIBP2) and 14q23.2 (rs58262369, P=6.05 × 10(-10); ESR2). 26443449 2015
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.120 GeneticVariation disease GWASCAT Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. 26443449 2015