PARG, poly(ADP-ribose) glycohydrolase, 8505

N. diseases: 50; N. variants: 2
Disease: Carcinoma of lung ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.030 Biomarker disease BEFREE These results indicate that PARG gene silencing protects mice against lung cancer induced by BaP inhalation exposure. 31130856 2019
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.030 Biomarker disease BEFREE Dual depletion of PARG and DUSP22 increased the apoptotic sub-G<sub>1</sub> fraction and upregulated <i>PUMA</i> in lung cancer A549, PC14, and SBC5 cells, and inhibited the PI3K/AKT/mTOR pathway in A549 cells, suggesting that dual depletion of PARG and DUSP22 induced apoptosis by upregulating <i>PUMA</i> and suppressing the PI3K/AKT/mTOR pathway. 31142510 2019
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.030 AlteredExpression disease BEFREE Here, we investigated whether PARG siRNA contributes to an increased radiosensitivity using 8 lung cancer cell lines. 24211580 2013