PARG, poly(ADP-ribose) glycohydrolase, 8505

N. diseases: 50; N. variants: 2
Disease: Brain Infarction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0751955
Disease: Brain Infarction
Brain Infarction 		0.200 Biomarker disease RGD We demonstrate that either pre- or post-ischemia treatment with 40 mg/kg of N-bis-(3-phenyl-propyl)9-oxo-fluorene-2,7-diamide, a novel PARG inhibitor, significantly reduces brain infarct volumes by 40-53% in a rat model of focal cerebral ischemia. 12834903 2003