PARG, poly(ADP-ribose) glycohydrolase, 8505

N. diseases: 50; N. variants: 2
Disease: Primary malignant neoplasm of lung ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.030 Biomarker disease BEFREE Dual depletion of PARG and DUSP22 increased the apoptotic sub-G<sub>1</sub> fraction and upregulated <i>PUMA</i> in lung cancer A549, PC14, and SBC5 cells, and inhibited the PI3K/AKT/mTOR pathway in A549 cells, suggesting that dual depletion of PARG and DUSP22 induced apoptosis by upregulating <i>PUMA</i> and suppressing the PI3K/AKT/mTOR pathway. 31142510 2019
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.030 Biomarker disease BEFREE These results indicate that PARG gene silencing protects mice against lung cancer induced by BaP inhalation exposure. 31130856 2019
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.030 AlteredExpression disease BEFREE Here, we investigated whether PARG siRNA contributes to an increased radiosensitivity using 8 lung cancer cell lines. 24211580 2013