Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.020 AlteredExpression phenotype BEFREE TWIST1, as an important factor responsible for metastasis of several cancers, is involved in tumor invasion and metastasis through indirectly regulation of MMP-21 expression. 31016793 2019
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.020 AlteredExpression disease BEFREE TWIST1, MMP-21, and HLAG-1 co-overexpression is associated with ESCC aggressiveness. 31016793 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.020 Biomarker phenotype BEFREE These results suggested the potential role of MMP-21 in the invasion and metastasis process of human colorectal cancer. 21656525 2011
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 AlteredExpression group BEFREE Expression of MMP-21 and MMP-28 seems to associate with the tumors of lesser malignant potential. 19921252 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 Biomarker group BEFREE MMP-21 may provide a marker for differentiating tumor areas. 16641547 2006
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.020 Biomarker disease BEFREE MMP-21 was detected basally in KYSE-30 and OE21 esophageal squamous cell carcinoma cells, while MMP-26 was absent. 16641547 2006
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 AlteredExpression group BEFREE Among epithelial MMPs, MMP-21 has a unique expression pattern in cancer. 14691307 2003
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 Biomarker phenotype BEFREE Human matrix metalloproteinase-21 (MMP-21), the newest member of the MMP gene family, has been suggested to play an important role in embryogenesis and tumor progression and to be a target of the Wnt, Pax, and Notch signaling pathways. 14691307 2003
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 AlteredExpression group BEFREE Among epithelial MMPs, MMP-21 has a unique expression pattern in cancer. 14691307 2003
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 Biomarker group BEFREE MMP-21 protein can also be detected in malignancies such as ovarian and colon carcinomas by immunohistochemical staining. 12490321 2002
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 Biomarker phenotype BEFREE Our findings suggest that MMP-21 functions in embryogenesis and tumor progression. 12490321 2002
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 AlteredExpression group BEFREE Matrix metalloproteinase-21, the human orthologue for XMMP, is expressed during fetal development and in cancer. 12490321 2002
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.010 Biomarker disease BEFREE Our results suggest that miR-4484, and MMP-21 might be novel serum biomarkers that may correspond to pathological fibrosis in SSc, but it needs to be validated in further studies. 31582779 2019
CUI: C4722419
Disease: Extrapulmonary Small Cell Carcinoma
Extrapulmonary Small Cell Carcinoma 		0.010 AlteredExpression disease BEFREE TWIST1, MMP-21, and HLAG-1 co-overexpression is associated with ESCC aggressiveness. 31016793 2019
CUI: C0019693
Disease: HIV Infections
HIV Infections 		0.010 GeneticVariation group BEFREE MMP-21 572CT genotype and early HIV disease stage showed a higher risk for the advancement of HIV disease with marginal significance (OR = 1.89, p = 0.07). 29575199 2018
CUI: C0029227
Disease: Delirium, Dementia, Amnestic, Cognitive Disorders
Delirium, Dementia, Amnestic, Cognitive Disorders 		0.010 GeneticVariation group BEFREE MMP-21 572TT genotype was predominantly higher in HAND patients compared with no HAND (OR = 1.63, p = 0.57). 29575199 2018
CUI: C4041080
Disease: Neurocognitive Disorders
Neurocognitive Disorders 		0.010 GeneticVariation group BEFREE MMP-21 572TT genotype was predominantly higher in HAND patients compared with no HAND (OR = 1.63, p = 0.57). 29575199 2018
CUI: C4285693
Disease: HIV-associated neurocognitive disorder
HIV-associated neurocognitive disorder 		0.010 GeneticVariation disease BEFREE Effect of matrix metalloproteinase-21 (572C/T) polymorphism on HIV-associated neurocognitive disorder. 29575199 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.010 AlteredExpression disease BEFREE High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis. 24700287 2014
CUI: C0024232
Disease: Lymphatic Metastasis
Lymphatic Metastasis 		0.010 AlteredExpression disease BEFREE Results showed that MMP-2 and VEGF-C expression levels in the PTs and MMP-2, MMP-21 and VEGF-C expression in the LNM foci correlated with the overall survival of the OSCC patients with lymphatic metastasis. 24700287 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.010 Biomarker disease BEFREE These results suggested the potential role of MMP-21 in the invasion and metastasis process of human colorectal cancer. 21656525 2011
CUI: C0677949
Disease: Stage III Colorectal Cancer
Stage III Colorectal Cancer 		0.010 Biomarker disease BEFREE MMP-21 was also proved to be an independent prognostic factor in patients with stage II as well as stage III colorectal cancer. 21656525 2011
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.010 Biomarker phenotype BEFREE These results suggested the potential role of MMP-21 in the invasion and metastasis process of human colorectal cancer. 21656525 2011
CUI: C3146250
Disease: Stage III Colorectal Cancer AJCC v7
Stage III Colorectal Cancer AJCC v7 		0.010 Biomarker disease BEFREE MMP-21 was also proved to be an independent prognostic factor in patients with stage II as well as stage III colorectal cancer. 21656525 2011
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.010 Biomarker disease BEFREE These results suggested the potential role of MMP-21 in the invasion and metastasis process of human colorectal cancer. 21656525 2011