ITGA8, integrin subunit alpha 8, 8516

N. diseases: 46; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1609433
Disease: Congenital absence of kidneys syndrome
Congenital absence of kidneys syndrome 		0.610 GeneticVariation disease BEFREE These results demonstrate that mutations of ITGA8 are a genetic cause of bilateral renal agenesis and that, at least in some cases, bilateral renal agenesis is an autosomal-recessive disease. 24439109 2014
CUI: C1609433
Disease: Congenital absence of kidneys syndrome
Congenital absence of kidneys syndrome 		0.610 GermlineCausalMutation disease ORPHANET These results demonstrate that mutations of ITGA8 are a genetic cause of bilateral renal agenesis and that, at least in some cases, bilateral renal agenesis is an autosomal-recessive disease. 24439109 2014
CUI: C1609433
Disease: Congenital absence of kidneys syndrome
Congenital absence of kidneys syndrome 		0.610 Biomarker disease CTD_human
CUI: C1609433
Disease: Congenital absence of kidneys syndrome
Congenital absence of kidneys syndrome 		0.610 Biomarker disease HPO
CUI: C1619700
Disease: RENAL ADYSPLASIA
RENAL ADYSPLASIA 		0.600 GeneticVariation disease UNIPROT Integrin alpha 8 recessive mutations are responsible for bilateral renal agenesis in humans. 24439109 2014
CUI: C1619700
Disease: RENAL ADYSPLASIA
RENAL ADYSPLASIA 		0.600 Biomarker disease GENOMICS_ENGLAND
CUI: C1619700
Disease: RENAL ADYSPLASIA
RENAL ADYSPLASIA 		0.600 CausalMutation disease CLINVAR
CUI: C1619700
Disease: RENAL ADYSPLASIA
RENAL ADYSPLASIA 		0.600 Biomarker disease GENOMICS_ENGLAND
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 Biomarker disease BEFREE These results suggest that the ITGA8 gene might have gender-specific roles in the development of schizophrenia. 23153507 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 Biomarker disease PSYGENET These results suggest that the ITGA8 gene might have gender-specific roles in the development of schizophrenia. 23153507 2013
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.310 Biomarker disease BEFREE Identification of PRTFDC1 silencing and aberrant promoter methylation of GPR150, ITGA8 and HOXD11 in ovarian cancers. 17303177 2007
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.310 Biomarker disease CTD_human In primary ovarian cancers, CGIs of GPR150 (in 4 of 15 cancers), ITGA8 (2/15), PRTFDC1 (1/15), and HOXD11 (1/15) were methylated. 17303177 2007
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.300 Biomarker disease CTD_human Quantitative expression of the homeobox and integrin genes in human gastric carcinoma. 17786296 2007
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.300 Biomarker group CTD_human Quantitative expression of the homeobox and integrin genes in human gastric carcinoma. 17786296 2007
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.300 Biomarker disease CTD_human Ten ovarian cancer cell lines were analyzed by methylation-specific PCR, and seven (GPR150, LOC222171, PRTFDC1, LOC339210, ITGA8, C9orf64 and HOXD11) of the 33 CGIs were methylated in one or more of the cell lines. 17303177 2007
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.300 Biomarker disease CTD_human Quantitative expression of the homeobox and integrin genes in human gastric carcinoma. 17786296 2007
CUI: C0221238
Disease: Mesangial proliferative glomerulonephritis
Mesangial proliferative glomerulonephritis 		0.200 Biomarker disease RGD Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells. 25482639 2014
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.110 Biomarker disease BEFREE These data suggested that DLG2, but not TMEM229B, GPNMB, and ITGA8, influenced the risk of PD in Taiwan. 29290481 2018
CUI: C0265783
Disease: Congenital hypoplasia of lung
Congenital hypoplasia of lung 		0.110 Biomarker disease BEFREE Decreased expression of Itga3, Itga6, and Itga8 in the pulmonary mesenchyme may lead to disruptions in airway branching morphogenesis, thus contributing to PH in the nitrofen-induced CDH model. 28701000 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.110 GeneticVariation disease GWASCAT A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci. 28892059 2017
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.110 GeneticVariation disease GWASDB Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815 2012
CUI: C0265783
Disease: Congenital hypoplasia of lung
Congenital hypoplasia of lung 		0.110 Biomarker disease HPO
CUI: C0004096
Disease: Asthma
Asthma 		0.100 GeneticVariation disease GWASCAT Genome-Wide Association Study Identifies Novel Loci Associated With Diisocyanate-Induced Occupational Asthma. 25918132 2015
CUI: C0008925
Disease: Cleft Palate
Cleft Palate 		0.100 Biomarker disease HPO
CUI: C0009081
Disease: Congenital clubfoot
Congenital clubfoot 		0.100 Biomarker disease HPO