|
Contact Dermatitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay.
|
25724174 |
2015 |
|
Contact hypersensitivity
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay.
|
25724174 |
2015 |
|
Osteoporosis
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Sex-specific effect of Pirin gene on bone mineral density in a cohort of 4000 Chinese.
|
19766747 |
2010 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Moreover, the miR-455-5p/PIR axis contributed to cancer cell aggressiveness.
|
30444038 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Moreover, the miR-455-5p/PIR axis contributed to cancer cell aggressiveness.
|
30444038 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
On the basis of <i>FGFR3</i> mutation status and methylation of <i>GATA2</i>, this cohort could be reclassified into a good class (PIR = 0.86, 26.2% of patients), a moderate class (PIR = 4.32, 49.7%), and a poor class (PIR = 7.66, 24.0%).<b>Conclusions:</b> We conclude that the addition of selected biomarkers to the EAU risk stratification increases its accuracy and identifies a subset of NMIBC patients with a very high risk of progression.<i>Clin Cancer Res; 24(7); 1586-93.©2018 AACR</i>.
|
29367430 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
On the basis of <i>FGFR3</i> mutation status and methylation of <i>GATA2</i>, this cohort could be reclassified into a good class (PIR = 0.86, 26.2% of patients), a moderate class (PIR = 4.32, 49.7%), and a poor class (PIR = 7.66, 24.0%).<b>Conclusions:</b> We conclude that the addition of selected biomarkers to the EAU risk stratification increases its accuracy and identifies a subset of NMIBC patients with a very high risk of progression.<i>Clin Cancer Res; 24(7); 1586-93.©2018 AACR</i>.
|
29367430 |
2018 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Our results suggest that PSK may augment anti-tumour action via genes including multidrug resistance protein 3 (MRP3), lymphotactin (Lptn), transgelin (TAGLN), and Pirin, without disturbing cell-cycle progression, and may deserve a large clinical trial in cancer therapy.
|
15547752 |
2004 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Our results suggest that PSK may augment anti-tumour action via genes including multidrug resistance protein 3 (MRP3), lymphotactin (Lptn), transgelin (TAGLN), and Pirin, without disturbing cell-cycle progression, and may deserve a large clinical trial in cancer therapy.
|
15547752 |
2004 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Here we report that knockdown of <i>PIR</i> in MCF7 and MDA-MB-231 cell lines causes a dramatic decrease in cell proliferation and xenograft tumor growth in mice.
|
31500513 |
2019 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, knockdown of <i>PIR</i> significantly decreases the abilities of MCF7 cells for mobility and invasion in vitro and their metastasis in mice, which may be attributed to the decrease of DDR1.
|
31500513 |
2019 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Loss-of-function assays using siRNA or an inhibitor (bisamide) showed that downregulation of PIR expression blocked cancer cell migration and invasion.
|
30444038 |
2019 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Downregulation of the three metastasis-associated proteins ALDH1A1, PIR and PDCD4 in miR-155-overexpressing tumors was validated by immunohistochemistry.
|
26317550 |
2015 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
PIR promotes tumorigenesis of breast cancer by upregulating cell cycle activator E2F1.
|
31500513 |
2019 |
|
Lung diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
SIRT1 functions as a protector from PM exposure, whereas PIR acts as a predictor of PM-induced pulmonary disease.
|
31299012 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
An <i>in silico</i> analysis revealed that PIR correlated with smoke exposure and early COPD.
|
31299012 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, knockdown of <i>PIR</i> significantly decreases the abilities of MCF7 cells for mobility and invasion in vitro and their metastasis in mice, which may be attributed to the decrease of DDR1.
|
31500513 |
2019 |
|
Carcinogenesis
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
In conclusion, PIR stimulates tumorigenesis and progression by activating E2F1 and its target genes.
|
31500513 |
2019 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
PIR promotes tumorigenesis of breast cancer by upregulating cell cycle activator E2F1.
|
31500513 |
2019 |
|
Hormone refractory prostate cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PIR expression was directly regulated by miR-455-5p, and PIR overexpression was detected in hormone-sensitive prostate cancer (HSPC) surgical specimens and CRPC autopsy specimens.
|
30444038 |
2019 |
|
Hormone sensitive prostate cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PIR expression was directly regulated by miR-455-5p, and PIR overexpression was detected in hormone-sensitive prostate cancer (HSPC) surgical specimens and CRPC autopsy specimens.
|
30444038 |
2019 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have reported that PIR-A/B<sup>high</sup> cDCs (conventional DCs) appeared in dextran sodium sulfate (DSS)-induced colitis and serve as a negative immunoregulator in an animal model of IBD.
|
29508072 |
2018 |
|
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
We have reported that PIR-A/B<sup>high</sup> cDCs (conventional DCs) appeared in dextran sodium sulfate (DSS)-induced colitis and serve as a negative immunoregulator in an animal model of IBD.
|
29508072 |
2018 |
|
Carcinoma of urinary bladder, invasive
|
0.010 |
Biomarker
|
disease |
BEFREE |
On the basis of <i>FGFR3</i> mutation status and methylation of <i>GATA2</i>, this cohort could be reclassified into a good class (PIR = 0.86, 26.2% of patients), a moderate class (PIR = 4.32, 49.7%), and a poor class (PIR = 7.66, 24.0%).<b>Conclusions:</b> We conclude that the addition of selected biomarkers to the EAU risk stratification increases its accuracy and identifies a subset of NMIBC patients with a very high risk of progression.<i></i>.
|
29367430 |
2018 |
|
Arthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
With regards to the clinical course of the disease, high frequencies of PIR-B<sup>+</sup> CD4<sup>+</sup> T cells were found to be associated with a milder course of arthritis, suggesting that the net effect of PIR-B expression is suppression of autoreactive T cells.
|
28664612 |
2017 |