|
Carcinomatosis of peritoneal cavity
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we show that a toll-like receptor (TLR) and C-type lectin receptor (CLR) agonist pairing of monophosphoryl lipid A (MPL) and trehalose-6,6'-dicorynomycolate (TDCM) effectively inhibits tumor growth and ascites development in a mouse model of aggressive mammary cancer-induced peritoneal carcinomatosis.
|
30224373 |
2019 |
|
Ewings sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we evaluated the in vivo pharmacokinetics of <sup>124</sup>I-CLR1404 (CLR 124) and estimated theranostic dosimetry for <sup>131</sup>I-CLR1404 (CLR 131) MRT in murine xenograft models of the pediatric solid tumors neuroblastoma, rhabdomyosarcoma, and Ewing sarcoma.
|
30926646 |
2019 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we evaluated the in vivo pharmacokinetics of <sup>124</sup>I-CLR1404 (CLR 124) and estimated theranostic dosimetry for <sup>131</sup>I-CLR1404 (CLR 131) MRT in murine xenograft models of the pediatric solid tumors neuroblastoma, rhabdomyosarcoma, and Ewing sarcoma.
|
30926646 |
2019 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we evaluated the in vivo pharmacokinetics of <sup>124</sup>I-CLR1404 (CLR 124) and estimated theranostic dosimetry for <sup>131</sup>I-CLR1404 (CLR 131) MRT in murine xenograft models of the pediatric solid tumors neuroblastoma, rhabdomyosarcoma, and Ewing sarcoma.
|
30926646 |
2019 |
|
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
DCLK3 also produced beneficial effects on motor symptoms in a knock-in mouse model of Huntington's disease.
|
29534157 |
2018 |
|
Leishmaniasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, little is known about the function of the CLR Dectin-1 in modulating Th1- or Th2-type immune responses by DC subsets in leishmaniasis.
|
29535708 |
2018 |
|
Migraine Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (CLR + RAMP1) offer considerable improvements over existing drugs in migraine prophylaxis and are the first designed to act on the trigeminal pain system.
|
30550780 |
2018 |
|
Secondary malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In vivo antitumor efficacy was tested by injecting nude mice bearing either MDA-MB-231-luc orthotopic xenografts or lung metastases with 74 MBq (3.7 GBq/kg) of CLR 125 or an equivalent mass amount of nonradiolabeled CLR 125.
|
29641256 |
2018 |
|
Motor symptoms
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
DCLK3 also produced beneficial effects on motor symptoms in a knock-in mouse model of Huntington's disease.
|
29534157 |
2018 |
|
Triple Negative Breast Neoplasms
|
0.010 |
Biomarker
|
disease |
BEFREE |
Targeted radionuclide therapy with CLR 125 displayed significant antitumor efficacy in vivo, suggesting promise for treatment of TNBC micrometastases.
|
29641256 |
2018 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Targeted radionuclide therapy with CLR 125 displayed significant antitumor efficacy in vivo, suggesting promise for treatment of TNBC micrometastases.
|
29641256 |
2018 |
|
Cerebrovascular accident
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We selected five SNPs from among the CLR variants (rs77035639, rs3815524, rs75380157, rs574603859, and rs147565266) and one RAMP2 SNP (rs753152), which were associated with stroke, for analysis.
|
28904253 |
2017 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of MICL were not associated with disease in patients with RA, but this CLR was the target of autoantibodies in a subset of patients with RA.
|
26275430 |
2016 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Collectively, these results highlight the hitherto poorly understood mechanism of Kupffer cell-mediated control of metastasis that is mediated by the CLR innate receptor family, with implications for the development of anticancer therapy targeting CLRs.
|
27872290 |
2016 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, the present findings suggest that synovial macrophages are the major producers of IL-1β and regulators of CLR in OA mice.
|
26400621 |
2016 |
|
Staphylococcal Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
For CLR and the remaining subtypes, links among the 3 methods were generally poor.Bovine Staph. aureus is highly clonal and a few clones predominate.Animal Staph. aureus always evolve from human strains, such that every human strain may be the ancestor of a novel animal-adapted strain.
|
26601578 |
2016 |
|
Secondary malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, macrophage C-type lectin, a CLR known to be complex with Dectin-2, also contributes to the suppression of liver metastasis.
|
27872290 |
2016 |
|
Malignant Pleural Mesothelioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Real time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) was used to assess the steady-state levels of AM, CLR, RAMP2 and RAMP3 messenger RNA (mRNA) transcripts in normal pleural tissue (n=5) and MPM (n=24).
|
26762744 |
2016 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, since RAMP-receptor interfaces are pharmacologically tractable, it may be possible to develop compounds targeting the RAMP1/CLR interface to assist in the treatment of asthma.
|
25010197 |
2014 |
|
Allergic asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, we found that a 50% reduction of CLR, the G-protein receptor component of the CGRP receptor, also ameliorated airway resistance and inflammation in this model of allergic asthma.
|
25010197 |
2014 |
|
Neoplasms, Vascular Tissue
|
0.010 |
Biomarker
|
group |
BEFREE |
We therefore investigated the diagnostic/prognostic use for CLR in human tumor types that may rely on adrenomedullin signaling and in clear cell renal cell carcinoma (RCC), a highly vascular tumor, in particular.
|
23969937 |
2013 |
|
Chronic acquired lymphedema
|
0.010 |
Biomarker
|
disease |
BEFREE |
AM and its putative receptor calcitonin receptor-like receptor (CLR) are implicated in angiogenesis and lymphangiogenesis during embryogenesis and wound healing, suggesting their possible involvement in secondary lymphedema.
|
23364478 |
2013 |
|
Tumor Angiogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The G-protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) and its ligand peptide adrenomedullin (encoded by ADM gene) are implicated in tumor angiogenesis in mouse models but poorly defined in human cancers.
|
23969937 |
2013 |
|
Varicosity
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the proximal colon and ileum, CLR was found in nerve varicosities of the myenteric plexus and surrounding submucosal neurons.
|
22484227 |
2012 |
|
Cervical Intraepithelial Neoplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here we showed that the development of cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma (CSCC) in Uighur women was accompanied with the partial or total loss of protein expression of HLA-I, ß2-m and APM components, including the transporter associated with antigen processing (TAP1/2), low molecular mass protein (LMP2, LMP7), endoplasmic reticulum aminopeptidase 1(ERAP1), chaperone molecules include calreticulin (CLR), calnexin (CNX) and ERp57, and this was proved again by analysis of transcription of the same genes in addition to three genes HLA-A, B and C coding for HLA-I.
|
23024775 |
2012 |