|
Dermatitis, Atopic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
TSLP variation was determined using targeted massively parallel sequencing in a longitudinal cohort of children with AD.
|
31491540 |
2019 |
|
Dermatitis, Atopic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We identified that the susceptibility loci at 5q31 (RAD50/IL13, rs2158177, P = 1.08×10-3, OR = 1.15) and 5q22.1 (TSLP, rs1837253, P = 2.66×10-3, OR = 0.91) were significantly associated with AD.
|
28364410 |
2017 |
|
Dermatitis, Atopic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Also, TSLP polymorphisms are associated with susceptibility to asthma, atopic dermatitis, and eczema herpeticum.
|
22948028 |
2013 |
|
Dermatitis, Atopic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the joint effect of allergic sensitization and TSLP polymorphisms on AD and to test whether TSLP polymorphisms increase the risk of asthma in children with AD.
|
26712523 |
2016 |
|
Dermatitis, Atopic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The TSLP variation is associated with less persistent AD.
|
24401911 |
2014 |
|
Dermatitis, Atopic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
TSLP genetic variants and its dysregulated expression have been linked to atopic diseases such as atopic dermatitis, asthma, allergic rhinitis and eosinophilic esophagitis.
|
25340427 |
2014 |
|
Dermatitis, Atopic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Methylation status of the TSLP 5'-CpG island (CGI) was found to be significantly associated with prenatal smoke exposure (OR = 3.17, 95% CI = 1.63-6.19) and with AD (OR = 2.32, 95% CI = 1.06-5.11).
|
23600544 |
2013 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma.
|
20656951 |
2011 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To analyze the polymorphism of the two SNPs Rs2289276 and Rs2289278 in TSLP gene and to evaluate the association between the two SNPs and asthma susceptibility in Chinese Han population by using case-control study.
|
22913730 |
2012 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Several unanswered questions concerning basic pathophysiological aspects of TSLP variants, the long-term safety and efficacy of tezepelumab with different phenotypes/endotypes of asthma should be addressed.
|
31549891 |
2019 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, this study aimed to determine the associations of IL1RL1 rs3771180 and TSLP rs1837253 with asthma in Zhuang people.
|
31066119 |
2019 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Haplotype-specific score test indicated that an elevated risk for asthma was associated with a specific haplotype of TSLP involving SNP rs1898671 (OR = 1.58, 95% CI: 1.10-2.27, p = 0.01).
|
21966427 |
2011 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Identifying the polymorphisms in the thymic stromal lymphopoietin receptor (TSLPR) and their association with asthma.
|
20663412 |
2010 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
TSLP variants are associated with asthma in a sex-specific fashion.
|
20560908 |
2010 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Variants in the gene encoding the TSLP protein may have differential effects on asthma phenotypes depending on gender, atopy, and the presence of allergic rhinitis.
|
24525665 |
2014 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We selected 6 single nucleotide polymorphisms in thymic stromal lymphopoietin and genotyped 5565 individuals from 4 independent asthma studies and tested for association with asthma, atopy, atopic asthma, and airway hyperresponsiveness by using a general allelic likelihood ratio test.
|
19539984 |
2009 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Sputum cells (ISCs) from 5 moderate asthmatics and 5 healthy controls (HC) were stimulated either with TNF-α or TNF-α plus recombinant IL-37 (rIL-37) comparing the suppression on TSLP production.
|
27528425 |
2016 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In addition, as our group recently found that TSLP variants are associated with asthma and reduced lung function, we assessed whether TSLP single nucleotide polymorphisms (SNPs) were associated with baseline lung function in non-COPD, nonasthmatic healthy subjects (n = 1368).
|
21468164 |
2011 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups.
|
21804549 |
2011 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In contrast, the presence or absence of TSLP minor alleles did not affect asthma risk in subjects without the SPINK5 risk alleles.
|
24831437 |
2014 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Several monoclonal antibodies (mAbs) targeting pathogenetic molecules (e.g., IgE, IL-5, IL- 5Rα, IL-4, IL-13, TSLP) are currently available or under development for the treatment of different forms of severe type 2 asthma.
|
29318959 |
2019 |
|
Eosinophilic esophagitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We tested for gene-environment interaction between EoE-predisposing polymorphisms (within TSLP, LOC283710/KLF13, CAPN14, CCL26, and TGFB) and implicated early-life factors (antibiotic use in infancy, cesarean delivery, breast-feeding, neonatal intensive care unit [NICU] admission, and absence of pets in the home).
|
29029802 |
2018 |
|
Eosinophilic esophagitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
TSLP genetic variants and its dysregulated expression have been linked to atopic diseases such as atopic dermatitis, asthma, allergic rhinitis and eosinophilic esophagitis.
|
25340427 |
2014 |
|
Eosinophilic esophagitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.
|
25017104 |
2014 |