TSLP, thymic stromal lymphopoietin, 85480

N. diseases: 220; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.600 Biomarker disease MGD
CUI: C0017662
Disease: Glomerulonephritis, Membranoproliferative
Glomerulonephritis, Membranoproliferative 		0.510 Biomarker disease MGD
CUI: C0010403
Disease: Cryoglobulinemia
Cryoglobulinemia 		0.220 Biomarker disease MGD
CUI: C0002880
Disease: Autoimmune hemolytic anemia
Autoimmune hemolytic anemia 		0.200 Biomarker disease MGD
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.600 AlteredExpression disease BEFREE TSLP was highly expressed by epithelial cells, especially keratinocytes from patients with atopic dermatitis. 12055625 2002
CUI: C0013595
Disease: Eczema
Eczema 		0.100 AlteredExpression disease BEFREE TSLP was highly expressed by epithelial cells, especially keratinocytes from patients with atopic dermatitis. 12055625 2002
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.600 AlteredExpression disease BEFREE Skin-specific overexpression of TSLP resulted in an AD-like phenotype, with the development of eczematous lesions containing inflammatory dermal cellular infiltrates, a dramatic increase in Th2 CD4+ T cells expressing cutaneous homing receptors, and elevated serum levels of IgE. 16103410 2005
CUI: C0004096
Disease: Asthma
Asthma 		0.500 AlteredExpression disease BEFREE We used in situ hybridization and immunohistochemistry to examine the expression and cellular provenance of TSLP, Th2-attracting (thymus and activation-regulated chemokine (TARC)/CCL17, macrophage-derived chemokine (MDC)/CCL22, I-309/CCL1) and Th1-attracting (IFN-gamma-inducible protein 10 (IP-10)/CXCL10, IFN-inducible T cell alpha-chemoattractant (I-TAC)/CXCL11) chemokines and expression of their receptors CCR4, CCR8, and CXCR3 in bronchial biopsies from 20 asthmatics and 15 normal controls. 15944327 2005
CUI: C0004096
Disease: Asthma
Asthma 		0.500 AlteredExpression disease LHGDN Our data implicate TSLP, TARC/CCL17, MDC/CCL22, and IP-10/CXCL10 in asthma pathogenesis. 15944327 2005
CUI: C0013595
Disease: Eczema
Eczema 		0.100 AlteredExpression disease BEFREE Skin-specific overexpression of TSLP resulted in an AD-like phenotype, with the development of eczematous lesions containing inflammatory dermal cellular infiltrates, a dramatic increase in Th2 CD4+ T cells expressing cutaneous homing receptors, and elevated serum levels of IgE. 16103410 2005
CUI: C0001883
Disease: Airway Obstruction
Airway Obstruction 		0.020 Biomarker group BEFREE TSLP and TARC/CCL17 expression correlated with airway obstruction. 15944327 2005
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.600 Biomarker disease BEFREE We show here that topical application of the physiologically active ligand [1alpha,25-(OH)(2)D(3); calcitriol] of the vitamin D receptor, or of its low-calcemic analog MC903 (calcipotriol; Dovonex), induces TSLP expression in epidermal keratinocytes, which results in an atopic dermatitis-like syndrome mimicking that seen in RXRalphabeta(ep-/-) mutants and transgenic mice overexpressing TSLP in keratinocytes. 16880407 2006
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.600 Biomarker disease CTD_human We show here that topical application of the physiologically active ligand [1alpha,25-(OH)(2)D(3); calcitriol] of the vitamin D receptor, or of its low-calcemic analog MC903 (calcipotriol; Dovonex), induces TSLP expression in epidermal keratinocytes, which results in an atopic dermatitis-like syndrome mimicking that seen in RXRalphabeta(ep-/-) mutants and transgenic mice overexpressing TSLP in keratinocytes. 16880407 2006
CUI: C0086196
Disease: Eczema, Infantile
Eczema, Infantile 		0.300 Biomarker disease CTD_human Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. 16880407 2006
CUI: C0013595
Disease: Eczema
Eczema 		0.100 Biomarker disease BEFREE We show here that topical application of the physiologically active ligand [1alpha,25-(OH)(2)D(3); calcitriol] of the vitamin D receptor, or of its low-calcemic analog MC903 (calcipotriol; Dovonex), induces TSLP expression in epidermal keratinocytes, which results in an atopic dermatitis-like syndrome mimicking that seen in RXRalphabeta(ep-/-) mutants and transgenic mice overexpressing TSLP in keratinocytes. 16880407 2006
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.600 Biomarker disease LHGDN The direct link between TSLP expression with the pathogenesis of atopic dermatitis and asthma in vivo was demonstrated. 17666213 2007
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.600 Biomarker disease BEFREE Compelling evidence suggests that the epithelial cell-derived cytokine thymic stromal lymphopoietin (TSLP) may initiate asthma or atopic dermatitis through a dendritic cell-mediated T helper (Th)2 response. 17242164 2007
CUI: C0017662
Disease: Glomerulonephritis, Membranoproliferative
Glomerulonephritis, Membranoproliferative 		0.510 Biomarker disease CTD_human ATRA is not protective but instead aggravates cryoglobulinaemic MPGN and its systemic manifestations in TSLP tg mice. 17686814 2007
CUI: C0004096
Disease: Asthma
Asthma 		0.500 Biomarker disease BEFREE Compelling evidence suggests that the epithelial cell-derived cytokine thymic stromal lymphopoietin (TSLP) may initiate asthma or atopic dermatitis through a dendritic cell-mediated T helper (Th)2 response. 17242164 2007
CUI: C0004096
Disease: Asthma
Asthma 		0.500 Biomarker disease LHGDN The direct link between TSLP expression with the pathogenesis of atopic dermatitis and asthma in vivo was demonstrated. 17666213 2007
CUI: C0021368
Disease: Inflammation
Inflammation 		0.310 AlteredExpression phenotype LHGDN Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease. 17513456 2007
CUI: C0001925
Disease: Albuminuria
Albuminuria 		0.300 Biomarker phenotype CTD_human All-trans-retinoic acid aggravates cryoglobulin-associated membranoproliferative glomerulonephritis in mice. 17686814 2007
CUI: C0268742
Disease: Membranoproliferative Glomerulonephritis, Type I
Membranoproliferative Glomerulonephritis, Type I 		0.300 Biomarker disease CTD_human All-trans-retinoic acid aggravates cryoglobulin-associated membranoproliferative glomerulonephritis in mice. 17686814 2007
CUI: C0268743
Disease: Membranoproliferative Glomerulonephritis, Type II
Membranoproliferative Glomerulonephritis, Type II 		0.300 Biomarker disease CTD_human All-trans-retinoic acid aggravates cryoglobulin-associated membranoproliferative glomerulonephritis in mice. 17686814 2007
CUI: C1720821
Disease: Membranoproliferative Glomerulonephritis, Type III
Membranoproliferative Glomerulonephritis, Type III 		0.300 Biomarker disease CTD_human All-trans-retinoic acid aggravates cryoglobulin-associated membranoproliferative glomerulonephritis in mice. 17686814 2007