TSLP, thymic stromal lymphopoietin, 85480

N. diseases: 12; N. variants: 5
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.600 Biomarker disease CTD_human TSLP expression is enhanced in lesions with atopic dermatitis, and is a therapeutic target. 23688403 2013
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.600 Biomarker disease CTD_human These studies indicate that IL-13 induces AD and atopic march via a TSLP dependent mechanism. 22355542 2011
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.600 Biomarker disease CTD_human We show here that topical application of the physiologically active ligand [1alpha,25-(OH)(2)D(3); calcitriol] of the vitamin D receptor, or of its low-calcemic analog MC903 (calcipotriol; Dovonex), induces TSLP expression in epidermal keratinocytes, which results in an atopic dermatitis-like syndrome mimicking that seen in RXRalphabeta(ep-/-) mutants and transgenic mice overexpressing TSLP in keratinocytes. 16880407 2006
CUI: C0017662
Disease: Glomerulonephritis, Membranoproliferative
Glomerulonephritis, Membranoproliferative 		0.510 Biomarker disease CTD_human ATRA is not protective but instead aggravates cryoglobulinaemic MPGN and its systemic manifestations in TSLP tg mice. 17686814 2007
CUI: C0004096
Disease: Asthma
Asthma 		0.500 Biomarker disease CTD_human Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. 21804549 2011
CUI: C0341106
Disease: Eosinophilic esophagitis
Eosinophilic esophagitis 		0.500 Biomarker disease CTD_human Common variants at 5q22 associate with pediatric eosinophilic esophagitis. 20208534 2010
CUI: C0021368
Disease: Inflammation
Inflammation 		0.310 Therapeutic phenotype CTD_human Results suggest that short TSLP prevents airway inflammation in a chemical-induced asthma model, which might be associated with the inhibitions of HMGB1-RAGE and long TSLP expression and STAT5(Y694) phosphorylation. 28329851 2017
CUI: C0035228
Disease: Respiratory Hypersensitivity
Respiratory Hypersensitivity 		0.300 Therapeutic phenotype CTD_human Short Thymic Stromal Lymphopoietin Attenuates Toluene Diisocyanate-induced Airway Inflammation and Inhibits High Mobility Group Box 1-Receptor for Advanced Glycation End Products and Long Thymic Stromal Lymphopoietin Expression. 28329851 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.300 Biomarker disease CTD_human Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling. 28284560 2017
CUI: C0086196
Disease: Eczema, Infantile
Eczema, Infantile 		0.300 Biomarker disease CTD_human Suppressive effects of antimycotics on thymic stromal lymphopoietin production in human keratinocytes. 23688403 2013
CUI: C0086196
Disease: Eczema, Infantile
Eczema, Infantile 		0.300 Biomarker disease CTD_human The Role of TSLP in IL-13-induced atopic march. 22355542 2011
CUI: C0001925
Disease: Albuminuria
Albuminuria 		0.300 Biomarker phenotype CTD_human All-trans-retinoic acid aggravates cryoglobulin-associated membranoproliferative glomerulonephritis in mice. 17686814 2007
CUI: C0268742
Disease: Membranoproliferative Glomerulonephritis, Type I
Membranoproliferative Glomerulonephritis, Type I 		0.300 Biomarker disease CTD_human All-trans-retinoic acid aggravates cryoglobulin-associated membranoproliferative glomerulonephritis in mice. 17686814 2007
CUI: C0268743
Disease: Membranoproliferative Glomerulonephritis, Type II
Membranoproliferative Glomerulonephritis, Type II 		0.300 Biomarker disease CTD_human All-trans-retinoic acid aggravates cryoglobulin-associated membranoproliferative glomerulonephritis in mice. 17686814 2007
CUI: C1720821
Disease: Membranoproliferative Glomerulonephritis, Type III
Membranoproliferative Glomerulonephritis, Type III 		0.300 Biomarker disease CTD_human All-trans-retinoic acid aggravates cryoglobulin-associated membranoproliferative glomerulonephritis in mice. 17686814 2007
CUI: C0086196
Disease: Eczema, Infantile
Eczema, Infantile 		0.300 Biomarker disease CTD_human Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. 16880407 2006