Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, the scrib abrogated tumor showed the elevation of Drp-1 and reduced expression of Marf, which suggests enhanced mitochondrial-fission.
|
29360576 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results put forward a mechanism where COX-2 stimulates TFAM expression via p38-mediated DRP1/mitochondrial fragmentation signaling in irradiated tumor cells, which may be of value in understanding how to sensitize cancer cells during radiotherapy.
|
30862036 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Bioinformatics analysis revealed that CNPY2 was closely associated with the expression levels of 6 positive impact genes in HCC, namely, ROMO1, BOLA2, HSF1, ATG4B, ATF4, and DENR, which are implicated in the regulation of the tumor microenvironment.
|
30415246 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Migration and extravasation defects are also exhibited in Drp1-deficient mature T cells, unveiling its crucial role in controlling both T cell recirculation in secondary lymphoid organs and accumulation at tumor sites.
|
30540939 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Activation of Drp1 with E2F5-mimetic peptide for inducing Drp1 mitochondrial localization enhanced ceramide-mediated mitophagy and led to tumor suppression in HPV-negative HNSCC-derived xenograft tumors in response to cisplatin in SCID mice.
|
28606997 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, these findings highlight the importance of NIK in tumor pathogenesis and invite new therapeutic strategies that attenuate mitochondrial dysfunction through inhibition of NIK and Drp1.
|
27889261 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Whereas, Drp1 knockdown or treatment with mitochondrial division inhibitor-1 induced significant G1 phase arrest in HCC cells and reduced tumor growth in the xenotransplantation model.
|
27542250 |
2016 |
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth.
|
25658205 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Bax-PGAM5L-Drp1 complex is detected in arenobufagin and staurosporine treated CRC cells in vitro and in arenobufagin and cisplatin treated tumor in vivo as well.
|
26356820 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo findings confirmed that erucin-mediated inhibition of tumor growth in a breast cancer cell xenograft mouse model is associated with the mitochondrial translocation of cofilin and Drp1, fission and apoptosis.
|
25595902 |
2015 |