Previously, certain experiments have suggested that density-regulated re-initiation and release factor (<i>DENR</i>) could serve important roles in cancer, however, to the best of our knowledge, a comprehensive analysis of <i>DENR</i> and its association with cancer patient survival is lacking.
The identification of DENR and MCTS1 target transcripts will serve as a basis for future studies aimed at understanding the mechanistic involvement of DENR and MCTS1 in cancer and autism.
Our Drp1-directed large-scale analyses of the publically available cancer genomes reveal a robust correlation of Drp1 with cell-cycle genes in 29 of the 31 cancer types examined.