THOC5, THO complex 5, 8563

N. diseases: 17; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.300 GeneticVariation disease UNIPROT
CUI: C1261502
Disease: Finding of Mean Corpuscular Hemoglobin
Finding of Mean Corpuscular Hemoglobin 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.100 GeneticVariation phenotype GWASCAT THOC5: a novel gene involved in HDL-cholesterol metabolism. 24023261 2013
CUI: C1445957
Disease: Serum total cholesterol measurement
Serum total cholesterol measurement 		0.100 GeneticVariation phenotype GWASDB THOC5: a novel gene involved in HDL-cholesterol metabolism. 24023261 2013
CUI: C0002871
Disease: Anemia
Anemia 		0.010 Biomarker disease BEFREE Colla corii asini might upregulate ZNF471 and THOC5 by KRAB domain-containing zinc-finger protein pathway and THO complex subunit 5 pathway to improve anemia of pregnant women with β-thalassemia. 31098739 2019
CUI: C0005283
Disease: beta Thalassemia
beta Thalassemia 		0.010 Biomarker disease BEFREE Colla corii asini might upregulate ZNF471 and THOC5 by KRAB domain-containing zinc-finger protein pathway and THO complex subunit 5 pathway to improve anemia of pregnant women with β-thalassemia. 31098739 2019
CUI: C3841475
Disease: beta^+^ Thalassemia
beta^+^ Thalassemia 		0.010 Biomarker disease BEFREE Colla corii asini might upregulate ZNF471 and THOC5 by KRAB domain-containing zinc-finger protein pathway and THO complex subunit 5 pathway to improve anemia of pregnant women with β-thalassemia. 31098739 2019
CUI: C0002793
Disease: Anaplasia
Anaplasia 		0.010 Biomarker disease BEFREE Interestingly, mRNAs that lost THOC2 or THOC5 binding during VSMC dedifferentiation were enriched for genes important for the differentiated VSMC phenotype. 30026254 2018
CUI: C0022595
Disease: Keratosis Follicularis
Keratosis Follicularis 		0.010 AlteredExpression disease BEFREE Furthermore, RNA high-throughput sequencing (Seq) revealed that THOC5 silencing closely resembled the gene expression changes induced on PDGF (platelet-derived growth factor)-BB/PDGF-DD treatments in cultured VSMCs. 30026254 2018
CUI: C0042373
Disease: Vascular Diseases
Vascular Diseases 		0.010 Biomarker group BEFREE Our data introduce dynamic binding of THO to VSMC marker gene mRNAs as a novel mechanism contributing to VSMC phenotypic switching and imply THOC5 as a potential intervention node for vascular diseases. 30026254 2018
CUI: C0220726
Disease: Diastrophic dysplasia
Diastrophic dysplasia 		0.010 AlteredExpression disease BEFREE Furthermore, RNA high-throughput sequencing (Seq) revealed that THOC5 silencing closely resembled the gene expression changes induced on PDGF (platelet-derived growth factor)-BB/PDGF-DD treatments in cultured VSMCs. 30026254 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 Biomarker group BEFREE Finally we describe our recent data on selection of targeting candidates from THOC5 dependent genes for application in cancer therapy. 26828015 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 AlteredExpression group BEFREE THOC5 expression was enhanced in 78% of cytological differentiation grading G2 and G3 tumor in primary HCC. 26549021 2016
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.010 Biomarker group BEFREE Finally we describe our recent data on selection of targeting candidates from THOC5 dependent genes for application in cancer therapy. 26828015 2016
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.010 AlteredExpression disease BEFREE THOC5 expression was enhanced in 78% of cytological differentiation grading G2 and G3 tumor in primary HCC. 26549021 2016
CUI: C0023418
Disease: leukemia
leukemia 		0.010 Biomarker disease BEFREE We have investigated pathways for THOC5 phosphorylation to develop an understanding of THO complex modulation by tyrosine kinase (TK) oncogenes in leukemias. 23032722 2013
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.010 PosttranslationalModification disease BEFREE We show that THOC5 phosphorylation is elevated in stem cells from patients with chronic myeloid leukemia (CML) and that this phosphorylation is sensitive to the frontline drugs used in CML treatment. 23032722 2013