Degenerative polyarthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study revealed that the cartilage protective effect of osthole in a MIA-induced osteoarthritis (OA) murine model can be explained by downregulation of COX-2 and RUNX2 by inhibition of NF-κB and HIF-2α up-regulated by OA induction, resulting in downregulation of MMP-13, Syndecan IV and ADAMTS-5.
|
31765607 |
2020 |
Degenerative polyarthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
One month following MLI, the numbers of MMP13-positive and TUNEL-positive chondrocytes were significantly greater in the articular cartilage of the RUNX2 OE joints compared to control joints and 2 months following MLI, histomorphometry and Osteoarthritis Research Society International (OARSI) scoring revealed decreased cartilage area in the RUNX2 OE joints.
|
31189030 |
2019 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
When locally administered in vivo in an OA mouse model, the hydrogels demonstrated the ability to restore, to some extent, bone remineralization, proteoglycan production, levels of Sox-9 and Runx-2.
|
30968404 |
2019 |
Degenerative polyarthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate the role of Notch signaling changes during proliferation and differentiation of chondrocyte, and to testify the mechanism of MMP-13 regulation by Notch and Runx2 expression changes during osteoarthritis.
|
31666602 |
2019 |
Degenerative polyarthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
After stimulation with IL-1β or fibronectin fragments, we showed that ERK inhibition decreased Runx2 activation and ADAMTS-12 expression in OA-SF, also reducing Fn-fs-induced COMP degradation.
|
30903650 |
2019 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Downregulation of histone deacetylase-4 (HDAC4) contributes to cartilage degeneration in osteoarthritis (OA) because it promotes upregulation of runt-related transcription factor-2 (Runx-2) and osteoarthritis-related genes.
|
31310910 |
2019 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The expression levels of 15-LOX-1 along with osteoblast phenotype markers such as RUNX2, COL1, and OCN were significantly increased in OA subchondral bone.
|
31704449 |
2019 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Runx2 is one of the genes responsible for the pathogenesis of osteoarthritis (OA) because RUNX2 is up-regulated in chondrocytes in OA cartilage and a germline haplodeficiency or deletion of Runx2 in articular chondrocytes decelerates OA progression.
|
29356961 |
2018 |
Degenerative polyarthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
It was identified that the expression of miR‑204‑5p was significantly decreased, whereas Runx2 was significantly increased, in human OA tissues compared with in non‑OA tissues, and levels were inversely associated with each other in primary chondrocytes and chondrosarcoma cells.
|
30106092 |
2018 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Finally, knocking down RUNX2 is insufficient to inhibit COL10A1 in OA-MSCs and also requires simultaneous knockdown of NOTCH1 thereby suggesting altered gene regulation in OA stem cells in comparison to chondrocytes.
|
29728632 |
2018 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Topological analysis of the PPI network revealed that numerous genes, including G protein subunit α1 (GNAI1), runt related transcription factor 2 (RUNX2) and integrin subunit β2 (ITGB2), may be involved in the development of OA.
|
29658578 |
2018 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
MSC-Exos increased chondrogenic genes Col2a1 (type II collagen alpha 1) and aggrecan, decreased hondrocyte hypertrophy markers MMP-13 (matrix metalloproteinase-13) and Runx2 (runt-related transcription factor 2) in chondrocytes isolated from OA model mice.
|
30324848 |
2018 |
Degenerative polyarthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We therefore posit that the OA signal mediates its effect by modulating the methylation of the regulatory element, which then impacts on gene expression, with RUNX2 being the principal target.
|
30010910 |
2018 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Bioinformatics analysis and experimental results from the literature were used to create and calibrate models of gene regulatory networks in OA involving miR-140 along with key regulators such as NF-κB, SMAD3, and RUNX2.
|
29095952 |
2017 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, our findings suggest that inhibition of Runx2 in chondrocytes could at least partially rescue DMM-induced OA-like defects in adult mice.
|
28539595 |
2017 |
Degenerative polyarthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, miR-320a could regulate the expression levels of BMI-1 and RUNX-2 proteins in OA chondrocytes (P<0.05).
|
29441992 |
2017 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present study demonstrated that PTH 1‑34 upregulated the Wnt/β‑catenin signaling pathway and that PTH1‑34 downregulated RUNX2 through an alternative pathway to the Wnt/β‑catenin signaling pathway, in a rat model of OA.
|
29039525 |
2017 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that RUNX2 gene transcription is regulated by the methylation status of specific CpG sites in the promoter and may determine RUNX2 availability in OA cartilage for transactivation of genes such as MMP13.
|
28798419 |
2017 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The cartilage damage was quantified using Osteoarthritis Research Society International score and matrix metalloproteinase (MMP)-3, -13, collagen (Col) X, Col 2, Runx2, and aggrecan (Acan) were detected by immunohistochemical analysis (IHC), ELISA, and RT-PCR.
|
28743292 |
2017 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, DKK1 and FRZB negatively correlated with OA grading, while RUNX2 and IHH showed a significantly positive correlation with OA grading.
|
27428952 |
2016 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, VIP and CRF reduced Runx2 and β-catenin activation in OA-SF.
|
26818776 |
2016 |
Degenerative polyarthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Runt-related transcription factor 2 (Runx2), a key transcription factor involved in OA, has been identified as a novel potential target of miR-105.
|
26816250 |
2016 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Decreased HDAC4 was associated with increased Runx2 and other OA-related genes in human OA cartilage, specifically: MMP-13, Ihh and type X collagen.
|
25424126 |
2014 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The compound knockout of Cebpb and Runx2 in mice caused growth retardation and resistance to OA with decreases in cartilage degradation and matrix metalloproteinase-13 (Mmp-13) expression.
|
22095691 |
2012 |
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Regulation of bone formation by RUNX2 and PPARγ2 is modified in OA compared to OP, resulting in higher osteoblastogenesis and adipogenesis in OA.
|
21854818 |
2011 |