|
Acute monocytic leukemia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Clinical significance of ASXL2 and ZBTB7A mutations and C-terminally truncated RUNX1-RUNX1T1 expression in AML patients with t(8;21) enrolled in the JALSG AML201 study.
|
30251205 |
2019 |
|
Acute monocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction.
|
31533028 |
2019 |
|
Acute monocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1.
|
31023702 |
2019 |
|
Acute monocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
RUNX1 mutations enhance self-renewal and block granulocytic differentiation in human in vitro models and primary AMLs.
|
30709863 |
2019 |
|
Acute monocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Negative CD19 expression is associated with inferior relapse-free survival in children with RUNX1-RUNX1T1-positive acute myeloid leukaemia: results from the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study.
|
31247675 |
2019 |
|
Acute monocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Prognostic Value of RUNX1 Mutations in AML: A Meta-Analysis
|
29479958 |
2018 |
|
Acute monocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Epigenetic heterogeneity affects the risk of relapse in children with t(8;21)RUNX1-RUNX1T1-rearranged AML.
|
29472719 |
2018 |
|
Acute monocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Number of RUNX1 mutations, wild-type allele loss and additional mutations impact on prognosis in adult RUNX1-mutated AML.
|
28751771 |
2018 |
|
Acute monocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mutations of RUNX1 gene can lead to acute leukemia and affect the prognosis of AML patients.
|
30289875 |
2018 |
|
Acute monocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Here, we assess the roles of the lncRNA CASC15 in regulation of a chromosomally nearby gene, SOX4, and its function in RUNX1/AML translocated leukemia.
|
28724437 |
2017 |
|
Acute monocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML.
|
28538183 |
2017 |
|
Acute monocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs.
|
27851970 |
2016 |
|
Acute monocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In multivariate analyses including a comprehensive set of molecular and clinical variables, we identified DNMT3A and RUNX1 mutations as important predictors of shorter overall survival (OS) in AML patients <60 years, and particularly in those with intermediate-risk cytogenetics.
|
27288520 |
2016 |
|
Acute monocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We have identified a new t(1;21)(p32;q22) chromosomal translocation in a MDS/AML patient that results in expression of an aberrant C-terminally truncated RUNX1 protein lacking several regulatory domains.
|
25798834 |
2016 |
|
Acute monocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells.
|
25928846 |
2015 |
|
Acute monocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Co-transduction of Kras(G12D) and AML1/ETO induces acute monoblastic leukemia.
|
24480914 |
2014 |
|
Acute monocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this review, we discuss the pathogenetic insights that have been gained from identifying the various events that can cooperate with AML1-ETO to induce AML in vivo.
|
22875638 |
2012 |
|
Acute monocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
AML with RUNX1 mutations are characterized by distinct genetic properties and are associated with resistance to therapy and inferior outcome.
|
21343560 |
2011 |
|
Acute monocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
These findings establish AES as a novel AML1/ETO-induced target gene that plays an important role in the self-renewal phenotype of t(8;21)-positive AML.
|
21245488 |
2011 |
|
Acute monocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, a subset of previously uncharacterized frame-shift and missense mutations at the N terminus of AML1, found in MDS and AML patients, impairs its interaction with MLL, resulting in loss of the H3K4me3 mark within PU.1 regulatory regions, and decreased PU.1 expression.
|
22012064 |
2011 |
|
Acute monocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
AML exhibiting the translocation t(8;21), which fuses the AML1 and ETO genes, has such a characteristic expression profile.
|
20460523 |
2010 |
|
Acute monocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We propose that RUNX1 mutations in this AML subgroup cause lineage infidelity, leading to aberrant coexpression of myeloid and B-lymphoid genes.
|
19666867 |
2009 |
|
Acute monocytic leukemia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Molecular cytogenetic findings in a three-way novel variant of t(1;8;21)(p35;q22;q22): a unique relocation of the AML1/ETO fusion gene 1p35 in AML-M2.
|
18206543 |
2008 |
|
Acute monocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
AML1 mutations induced MDS and MDS/AML in a mouse BMT model.
|
18192504 |
2008 |
|
Acute monocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.
|
18258796 |
2008 |