RUNX1, RUNX family transcription factor 1, 861

N. diseases: 412; N. variants: 75
Disease: Solid Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.050 Biomarker phenotype BEFREE In this review, we highlight evidence for RUNX1 control in both invertebrate and mammalian development and recent novel findings of perturbed RUNX1 control in breast cancer that has implications for other solid tumors. 30515788 2019
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.050 AlteredExpression phenotype BEFREE Runx1 is highly expressed in normal epithelium of most glands and recently has been associated with solid tumors. 28407681 2017
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.050 Biomarker phenotype BEFREE Recent studies also highlight the importance of RUNX1 in solid tumors both as a tumor promoter and a suppressor. 25263451 2015
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.050 GeneticVariation phenotype BEFREE Recent whole-exome sequencing also reveals mutations and deletions of RUNX1 in some solid tumors. 24752773 2014
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.050 Biomarker phenotype BEFREE EVI-1 is overexpressed in ovarian cancer compared with normal ovaries, suggesting a role for EVI-1 in solid tumour carcinogenesis or progression. 8932329 1996