Coronary Artery Disease
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Heritable variants in the final intron PLPP3 associate with interindividual variability in coronary artery disease risk that may result from disruption of enhancer sequences that normally act in <i>cis</i> to increase expression of the gene.
|
31362988 |
2019 |
Coronary Artery Disease
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Pharmacological targeting of bioactive LPP3 substrates, including LPA, may offer an orthogonal approach to lipid-lowering drugs for mitigation of coronary artery disease risk.
|
31533471 |
2019 |
Coronary Artery Disease
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Chromatin accessibility quantitative trait locus (caQTL) mapping using HAECs from 56 donors, allelic imbalance assay from 7 donors, and luciferase assays demonstrate that CAD/IS-protective allele at rs17114036 in PLPP3 intron 5 confers increased endothelial enhancer activity.
|
30429326 |
2018 |
Coronary Artery Disease
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.
|
30104761 |
2018 |
Coronary Artery Disease
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
In 2011, two genome-wide association studies have identified PLPP3 as a novel locus associated with coronary artery disease susceptibility.
|
29518748 |
2018 |
Coronary Artery Disease
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
Coronary Artery Disease
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females.
|
28061459 |
2017 |
Coronary Artery Disease
|
0.490 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies identified PLPP3 as a gene that plays a role in coronary artery disease susceptibility.
|
28291223 |
2017 |
Coronary Artery Disease
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses based on false discovery rate implicate new loci for coronary artery disease.
|
28714975 |
2017 |
Coronary Artery Disease
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
|
26343387 |
2015 |
Coronary Artery Disease
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate a genetic mechanism contributing to CAD risk at the PPAP2B locus and highlight the value of studying epigenetic changes in disease processes involving pathogenic environmental stimuli.
|
25835000 |
2015 |
Coronary Artery Disease
|
0.490 |
Biomarker
|
disease |
BEFREE |
PhosPhatidic Acid Phosphatase type 2B (PPAP2B), an integral membrane protein known as lipid phosphate phosphatase (LPP3) that inactivates lysophosphatidic acid, was implicated in coronary artery disease (CAD) by genome-wide association studies.
|
26034042 |
2015 |
Coronary Artery Disease
|
0.490 |
GeneticVariation
|
disease |
GWASDB |
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
|
24262325 |
2014 |
Coronary Artery Disease
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
These findings may provide a mechanistic link to explain the association between a PPAP2B polymorphism and coronary artery disease risk.
|
23104851 |
2013 |
Coronary Artery Disease
|
0.490 |
GeneticVariation
|
disease |
GWASDB |
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
23202125 |
2013 |
Coronary Artery Disease
|
0.490 |
Biomarker
|
disease |
CTD_human |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |