Both STC2 mRNA and protein expression are related to tumor diameter, stage, tumor metastasis, carcinoma emboli in the portal vein and the degree of tumor differentiation in HCC.
In the CRC tissues, high STC2 expression was significantly correlated with lymph node metastasis (<i>P</i>=0.047), distant metastasis (<i>P</i>=0.040), and advanced clinical stage (<i>P</i>=0.047).
In addition, STC2 gene probably promotes the development and metastasis of breast cancer by interacting with estrogen and ER, and it may become a new direction for breast cancer endocrine therapy.
We further show that STC2 upregulated the phosphorylation of AKT and enhanced HNSCC metastasis via Snail-mediated increase of vimentin and decrease of E-cadherin.