UNC5C, unc-5 netrin receptor C, 8633

N. diseases: 47; N. variants: 10
Disease: Malignant neoplasm of colon and/or rectum ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.080 PosttranslationalModification disease BEFREE Significant Pattern of Promoter Hypermethylation of UNC5C Gene in Colorectal Cancer and Its Implication in Late Stage 29801399 2018
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.080 AlteredExpression disease BEFREE However, there is little information available regarding the protein expression of UNC5C, the relationship between UNC5C protein expression and UNC5C methylation, and the correlation between patient clinical features and UNC5C protein expression in colorectal cancer. 28378635 2017
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.080 GeneticVariation disease BEFREE In conclusion, our results suggest that the contribution of germline mutations in UNC5C to hereditary colorectal cancer and to polyposis cases is negligible. 26852919 2016
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.080 GeneticVariation disease BEFREE Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles. 24415873 2014
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.080 GeneticVariation disease BEFREE Variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer. 21893118 2011
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.080 PosttranslationalModification disease BEFREE Recently, two reports indicated that UNC5C and DCC methylation was closely associated with loss of gene expression in colorectal cancer. 19242752 2009
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.080 PosttranslationalModification disease BEFREE UNC5C might act as a tumor suppressor and UNC5C methylation might present a malignant potential in colorectal cancer. 19331160 2009
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.080 Biomarker disease BEFREE Thus, the UNC5C dependence receptor is a tumor suppressor that regulates sporadic colorectal cancer. 17967459 2007