RUNX3, RUNX family transcription factor 3, 864

N. diseases: 281; N. variants: 16
Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.400 PosttranslationalModification disease BEFREE Therefore, we examined genetic and epigenetic alterations of RUNX3 in human HCC. 15780064 2005
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.400 PosttranslationalModification disease BEFREE Our findings indicate that promoter hypermethylation of RUNX3 gene may occur as an early event in the development of HCC and that methylation may be a major mechanism for inactivation of RUNX3 gene in HCC. 16155404 2005
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.400 Biomarker disease BEFREE RUNX3 methylation was also detected in hepatocellular carcinomas (73%, n=48), larynx cancers (62%, n=37), lung cancers (46%, n=24), breast cancers (25%, n=25), prostate cancers (23%, n=44), endometrial cancers (12.5%, n=24), colon cancers (4.9%, n=61) and uterine cervical cancers (2.5%, n=40), showing that RUNX3 methylation is not restricted to gastric cancer. 14968123 2004
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.400 PosttranslationalModification disease BEFREE Hemizygous deletion and hypermethylation of RUNX3 gene in hepatocellular carcinoma. 14760761 2004