|
Adenocarcinoma
|
0.390 |
Biomarker
|
group |
BEFREE |
Combination immunohistochemistry for SMAD4 and Runt-related transcription factor 3 may identify a favorable prognostic subgroup of pancreatic ductal adenocarcinomas.
|
29100342 |
2017 |
|
Adenocarcinoma
|
0.390 |
AlteredExpression
|
group |
BEFREE |
Our results showed two hypomethylated genes (CDKN2A and MGMT) and three hypermethylated genes (CDH13, RUNX3 and APC) in ACs compared with SCCs.
|
26862903 |
2016 |
|
Adenocarcinoma
|
0.390 |
PosttranslationalModification
|
group |
BEFREE |
The pooled OR was obtained from eleven studies including 271 squamous cell carcinoma and 389 adenocarcinoma (OR 0.41, confidence interval 0.19-0.89, P=0.02), which indicated that RUNX3 hypermethylation is significantly higher in adenocarcinoma that in squamous cell carcinoma.
|
26082616 |
2015 |
|
Adenocarcinoma
|
0.390 |
AlteredExpression
|
group |
BEFREE |
Targeted inactivation of Runx3 in mouse lung induced mucinous and nonmucinous adenomas and markedly shortened latency of adenocarcinoma formation induced by oncogenic K-Ras.
|
24229708 |
2013 |
|
Adenocarcinoma
|
0.390 |
AlteredExpression
|
group |
BEFREE |
Our results suggest a central role of RUNX3 downregulation in pulmonary adenocarcinoma, which may not be dependent of other established cancer-causing pathways and may have important diagnostic and screening implications.
|
22729835 |
2012 |
|
Adenocarcinoma
|
0.390 |
Biomarker
|
group |
CTD_human |
Varied pathways of stage IA lung adenocarcinomas discovered by integrated gene expression analysis.
|
21552421 |
2011 |
|
Adenocarcinoma
|
0.390 |
AlteredExpression
|
group |
BEFREE |
Folate concentrations and methylation of LINE-1, RASSF1, and RUNX3 were significantly higher in adenocarcinoma compared to squamous cell carcinoma (SCC).
|
19764999 |
2009 |
|
Adenocarcinoma
|
0.390 |
Biomarker
|
group |
BEFREE |
In conclusion, the hypermethylation of RASSF1A or RUNX3 gene is therefore a useful biomarker to predict the prognosis in NSCLC, particularly RASSF1A due to SCCs and RUNX3 due to ACs.
|
17606310 |
2007 |
|
Adenocarcinoma
|
0.390 |
PosttranslationalModification
|
group |
BEFREE |
RUNX3 methylation was significantly more frequent in non-smokers (16/43, 37.2%) than smokers (12/71, 16.9%; p=0.014), and in patients with AdC (26/72, 36.1%) than in patients with SqC (3/45, 6.7%; p<0.001).
|
16328045 |
2006 |
|
Adenocarcinoma
|
0.390 |
PosttranslationalModification
|
group |
BEFREE |
On the contrary, methylation of APC and RUNX3 was more frequent in adenocarcinomas than in squamous cell carcinomas (P < 0.05).
|
12841866 |
2003 |