|
Asthma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
CONCLUSIONS The methylation status of RUNX3 promoter region plays a role in Th1/Th2 imbalance by silencing RUNX3 gene expression, which can serve as predictive marker for the development of bronchiolitis into asthma.
|
31622282 |
2019 |
|
Asthma
|
0.350 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
|
Asthma
|
0.350 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
|
29785011 |
2018 |
|
Asthma
|
0.350 |
PosttranslationalModification
|
disease |
BEFREE |
Epigenetic regulation of Runx3 by DNA hypermethylation and microRNA, and the implication of these pathways in asthma are also discussed.
|
30218658 |
2018 |
|
Asthma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
miR-371, miR-138, miR-544, miR-145, and miR-214 could modulate Th1/Th2 balance in asthma through the combinatorial regulation of Runx3.
|
28804539 |
2017 |
|
Asthma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to determine the expression features of the Runx3 protein in a murine asthma model.
|
28962214 |
2017 |
|
Asthma
|
0.350 |
Biomarker
|
disease |
BEFREE |
Interestingly, these differences clustered in the genes highly associated with asthma (ORMDL family) and IgE regulation (RAD50, IL13, and IL4), but not in the T-regulatory genes (FOXP3, RUNX3).
|
23346934 |
2013 |
|
Asthma
|
0.350 |
Biomarker
|
disease |
MGD |
Thus, mutations in RUNX3 may be associated with increased sensitivity to asthma development.
|
16027362 |
2005 |
|
Asthma
|
0.350 |
Biomarker
|
disease |
MGD |
Runx3 is involved in hair shape determination.
|
15937937 |
2005 |
|
Asthma
|
0.350 |
Biomarker
|
disease |
MGD |
Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia.
|
15514019 |
2004 |
|
Asthma
|
0.350 |
Biomarker
|
disease |
MGD |
Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation.
|
14765120 |
2004 |
|
Asthma
|
0.350 |
Biomarker
|
disease |
MGD |
The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons.
|
12093746 |
2002 |