RUNX3, RUNX family transcription factor 3, 864
N. diseases: 281; N. variants: 16
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
|---|---|---|---|---|---|---|---|
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0.060 | Biomarker | disease | BEFREE | RUNX3 aberrations associated with HP (p = 0.04), high grade (p = 0.04), and advanced stage (p = 032). | 30553475 | 2018 |
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0.060 | GeneticVariation | disease | BEFREE | To evaluate the relationship among Helicobacter pylori (H. pylori) infection, CagA status, and dietary factors with RUNX3 promoter hypermethylation. | 23555166 | 2013 |
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0.060 | AlteredExpression | disease | BEFREE | An inverse relationship between the expression of the gastric tumor suppressor RUNX3 and infection with Helicobacter pylori in gastric epithelial dysplasia. | 24312710 | 2013 |
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0.060 | GeneticVariation | disease | BEFREE | Significant association of RUNX3 T/A polymorphism at intron 3 (rs760805) with the risk of gastric atrophy in Helicobacter pylori seropositive Japanese. | 19728008 | 2009 |
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0.060 | GeneticVariation | disease | BEFREE | Helicobacter pylori causes runx3 gene methylation and its loss of expression in gastric epithelial cells, which is mediated by nitric oxide produced by macrophages. | 19665002 | 2009 |
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0.060 | PosttranslationalModification | disease | BEFREE | Then, we correlated Runx3 methylation in the cancer tissue specimens with clinicopathological factors as well as the mucosal backgrounds, such as intestinal metaplasia surrounding the cancer cells and Helicobacter pylori (H. pylori) infection. | 18097595 | 2008 |