NCOA1, nuclear receptor coactivator 1, 8648

N. diseases: 108; N. variants: 7
Disease: Malignant neoplasm of prostate ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.390 Biomarker disease BEFREE SRC-1 has been shown to play an important role in the progression of breast cancer and prostate cancer. 30532986 2019
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.390 Biomarker disease BEFREE Studies in the field of prostate cancer frequently examined the role of p300/CBP and SRC-1 (NCOA1). 29786798 2018
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.390 AlteredExpression disease BEFREE Coactivators p300 and SRC-1 are required for AR activation by interleukin-6 (IL-6), a cytokine that is overexpressed in castration therapy-resistant prostate cancer. 26201947 2016
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.390 Biomarker disease BEFREE Protein kinase D1 (PRKD1) was found to be prominently up-regulated by NCOA1 knockdown in MDA PCa 2b, but not in PC3 cells. 27255895 2016
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.390 Biomarker disease BEFREE SRC-1 has been shown to play an important role in the progression of breast cancer and prostate cancer. 26082485 2015
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.390 AlteredExpression disease BEFREE The steroid receptor coactivator-1 (SRC-1) is highly expressed in breast, endometrial, and prostate cancer. 24705462 2014
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.390 Biomarker disease BEFREE The nuclear protein accumulation of SRC1 seems to be mildly increased in androgen ablation resistant prostate cancers.. 16894533 2006
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.390 AlteredExpression disease BEFREE Reduction of SRC-1 expression significantly reduced growth and altered androgen receptor target gene regulation in both LNCaP and C4-2 cell lines whereas it had no effect on the growth of the androgen receptor-negative PC-3 and DU145 prostate cancer cell lines. 16140968 2005
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.390 AlteredExpression disease BEFREE AR coactivators SRC-1 and TIF-2 are up-regulated in tissue specimens obtained from patients who failed prostate cancer endocrine therapy. 15663989 2004
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.390 Biomarker disease CTD_human The three coactivators, TIF-2, SRC-1 and RAC3, are up-regulated in relapsed prostate cancer. 12237244 2002