|
Colorectal Carcinoma
|
0.090 |
PosttranslationalModification
|
disease |
BEFREE |
The results showed increased SOCS-1 hypermethylation in CRC samples compared to controls.
|
27133036 |
2016 |
|
Colorectal Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Our results show that SOCS1 mRNA levels in tumours were more often elevated than reduced with respect to matched adjacent normal tissue of CRC specimens (n = 41).
|
26391193 |
2015 |
|
Colorectal Carcinoma
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The results of our study did not point towards a major role of the SOCS-1 -1478CA>del polymorphism in the pathogenesis of CC in Turkish subjects.
|
24460337 |
2013 |
|
Colorectal Carcinoma
|
0.090 |
PosttranslationalModification
|
disease |
BEFREE |
The aim of the present study was to examine the presence of DNA sequences of five human DNA viruses (assessed by PCR): JC polyoma virus (JCV), human adenovirus (AdV), Epstein-Barr virus (EBV), Kaposi sarcoma-associated herpesvirus (KSHV/HHV8) and human papillomavirus (HPV) in a cohort of 186 sporadic colorectal cancers (CRCs) and related these data with the methylation status of six CpG island methylator phenotype (CIMP)-specific genes (MLH1, CACNA1G, NEUROG1, IGF2, SOCS1, RUNX3) and seven cancer-related genes markers (p16, MINT1, MINT2, MINT31, EN1, SCTR and INHBB) assessed by methylation-specific PCR in 186 and 134 CRC cases, respectively.
|
21625944 |
2011 |
|
Colorectal Carcinoma
|
0.090 |
PosttranslationalModification
|
disease |
BEFREE |
Utilizing 903 population-based colorectal cancers and real-time PCR (MethyLight), we quantified DNA methylation in WRN and eight other promoters (CACNA1G, CDKN2A, CRABP1, IGF2, MLH1, NEUROG1, RUNX3 and SOCS1) known to be specific for CIMP.
|
18084250 |
2008 |
|
Colorectal Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Utilising MethyLight technology, we quantified DNA methylation in MGMT and eight other markers (a CIMP-diagnostic panel; CACNA1G, CDKN2A (p16), CRABP1, IGF2, MLH1, NEUROG1, RUNX3 and SOCS1) in 920 population-based colorectal cancers.
|
17339237 |
2007 |
|
Colorectal Carcinoma
|
0.090 |
PosttranslationalModification
|
disease |
BEFREE |
Aberrant methylation of HLTF, SOCS-1, and CDH13 genes is shown in colorectal cancers without lymph node metastasis.
|
15793636 |
2005 |
|
Colorectal Carcinoma
|
0.090 |
PosttranslationalModification
|
disease |
BEFREE |
Our findings suggest that inactivation of some tumor suppressor genes through aberrant promoter methylation of CpG islands may play a role in the development of colorectal cancer and methylation inactivation of these genes except p16 and SOCS1 may occur at the precancerous stage.
|
14719065 |
2004 |
|
Colorectal Carcinoma
|
0.090 |
PosttranslationalModification
|
disease |
BEFREE |
These findings suggested that SOCS-1 may act as a tumor suppressor in at least some colorectal cancers and that SOCS-1 methylation may be a particular phenomenon related to a nearly onset of colorectal cancer.
|
15074307 |
2004 |