SOCS1, suppressor of cytokine signaling 1, 8651

N. diseases: 315; N. variants: 7
Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.230 Biomarker disease BEFREE The Association between SOCS1-1656G>A Polymorphism, Insulin Resistance and Obesity in Nonalcoholic Fatty Liver Disease (NAFLD) Patients. 31717271 2019
CUI: C0028754
Disease: Obesity
Obesity 		0.230 Biomarker disease BEFREE SOCS3, but not SOCS1, gene silencing via siRNA increased the type I interferon response in PBMCs obtained from people with obesity. 27704310 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.230 GeneticVariation disease BEFREE Functional SOCS1 polymorphisms are associated with variation in obesity in whites. 19215277 2009
CUI: C0028754
Disease: Obesity
Obesity 		0.230 Biomarker disease RGD Since transgenic overexpression of SOCS-3 in islets reduced the lipopenic effect of leptin by 75%, we conclude that the increased expression of SOCS-1 and -3 in WAT of rats with acquired obesity could have blocked leptin's lipopenic action in the leptin-resistant WAT population. 11027633 2000