DYNLL1, dynein light chain LC8-type 1, 8655

N. diseases: 103; N. variants: 5
Disease: Malignant neoplasm of breast ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.050 AlteredExpression disease BEFREE The correlation between DLC-1 expression level and tumor progression and metastasis of breast cancer was negative. 22799310 2012
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.050 Biomarker disease BEFREE The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells. 16024604 2005
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.050 PosttranslationalModification disease BEFREE These data suggest that hypermethylation is responsible for silencing of DLC-1 gene in a limited portion of breast cancers. 15201975 2004
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.050 Biomarker disease BEFREE Our results indicate a role of DLC-1 in BC carcinogenesis. 12759748 2003
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.050 Biomarker disease BEFREE Furthermore, introduction of the DLC-1 cDNA abolished the in vivo tumorigenicity in nude mice, suggesting that the DLC-1 gene plays a role in breast cancer by acting as a bona fide tumor suppressor gene. 12545165 2003