IRS2, insulin receptor substrate 2, 8660

N. diseases: 152; N. variants: 6
Disease: Osteoporosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.220 Biomarker disease BEFREE MiRNA-7b-5p inhibits the adipogenic differentiation of hMSCs through IRS2, thus alleviating the development of osteoporosis. 31773671 2019
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.220 Biomarker disease RGD Altered gene expression involved in insulin signaling pathway in type II diabetic osteoporosis rats model. 22820932 2013
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.220 AlteredExpression disease LHGDN Collectively, our data show that altered osteoblast proliferation in human osteoporosis may result from dysregulation of IGF-I receptor signaling, including constitutive activation of the IRS-2/Erk signaling pathway, which becomes unresponsive to IGF-I, and defective induction of the IRS-1/Akt signaling pathway. 18079194 2008