IRS2, insulin receptor substrate 2, 8660

N. diseases: 152; N. variants: 6
Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 AlteredExpression disease BEFREE A high level of YAP/ TAZ expression was associated with a high level of IRS2 expression in human hepatocellular carcinoma (HCC). 29400692 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 Biomarker disease BEFREE Here, we investigated the roles of insulin receptor substrate (Irs) 1 and Irs2, both of which are the major molecules to be responsible for transducing insulin/IGF signaling in the liver, in the development of HCC by inducing chemical carcinogenesis using diethylnitrosamine (DEN) in mice. 28710407 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 GeneticVariation disease BEFREE IGF-2+3580 AA genotype, IGF-2+3123 GG genotype or G allele, IRS-2 1057 DD genotype and D allele were significantly associated with HCC risk. 24656929 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 Biomarker disease BEFREE We measured the expression levels of insulin receptor substrate 1 (IRS-1), IRS-2, and other factors involved in the insulin signal pathway in a human hepatoma cell line (Huh-7) transiently expressing the HCV core protein of genotypes 3a or 1b by molecular biology and biochemical techniques. 17465001 2007
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 Biomarker disease CTD_human In murine and human hepatoma cells, IRS-2 protein induction associated with increased IRS-2 mRNA levels. 16127164 2005
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.350 AlteredExpression disease BEFREE Here we report that insulin suppressed the expression of both IRS-1 and IRS-2 proteins in Fao hepatoma cells. 14596677 2003