|
Malignant neoplasm of prostate
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
The EIF3S3 overexpression was associated with increased fraction of cells in S-phase and with phosphorylation of retinoblastoma (Rb) protein. siRNA treatment inhibited significantly (P = 0.0022) the growth of all breast and prostate cancer cell lines studied.
|
16652384 |
2006 |
|
Malignant neoplasm of prostate
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
The data suggest that the expression of EIF3S3 is increased in prostate cancer, and that one of the mechanisms underlying the overexpression is the amplification of the gene.
|
14997205 |
2004 |
|
Malignant neoplasm of prostate
|
0.350 |
Biomarker
|
disease |
CTD_human |
The data suggest that the expression of EIF3S3 is increased in prostate cancer, and that one of the mechanisms underlying the overexpression is the amplification of the gene.
|
14997205 |
2004 |
|
Malignant neoplasm of prostate
|
0.350 |
Biomarker
|
disease |
BEFREE |
Eukaryotic translation initiation factor 3 subunit 3 does not seem to be overrepresented independent of c-myc in prostate cancer.
|
12000731 |
2002 |
|
Malignant neoplasm of prostate
|
0.350 |
Biomarker
|
disease |
BEFREE |
Here, we studied the frequency of the EIF3S3 amplification in different stages of prostate cancer and co-amplification of EIF3S3 and oncogene MYC.
|
11733359 |
2001 |
|
Malignant neoplasm of prostate
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
We have recently demonstrated that the EIF3S3 (eIF3-p40) gene, located at 8q23, is often amplified and overexpressed in both breast and prostate cancer.
|
10825005 |
2000 |
|
Colorectal Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Total eight common upregulated genes were found to be the CRC-related genes such as <i>RNF43</i> (ring finger protein 43), <i>EIF3H</i> (eukaryotic translation initiation factor 3 subunit H), and <i>STRAP</i> (serine/threonine kinase receptor associated protein).
|
31246501 |
2019 |
|
Colorectal Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
In conclusion, EIF3H plays key roles in the apoptosis in colorectal cancer cells, which suggests EIF3H as a potential diagnostic biomarker in colorectal cancer.
|
30022709 |
2018 |
|
Colorectal Carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
We show that increased expression of EIF3H gene increases CRC growth and invasiveness thereby providing a biological mechanism for the 8q23.3 association.
|
20862326 |
2010 |
|
Colorectal Carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 x 10(-13) overall; P = 6.9 x 10(-12) replication), and rs16892766, at 8q23.3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H.
|
18372905 |
2008 |
|
Prostatic Neoplasms
|
0.320 |
Biomarker
|
group |
CTD_human |
Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer.
|
14997205 |
2004 |
|
Prostatic Neoplasms
|
0.320 |
AlteredExpression
|
group |
LHGDN |
Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer.
|
14997205 |
2004 |
|
Prostatic Neoplasms
|
0.320 |
Biomarker
|
group |
BEFREE |
High-level amplification of eIF3-p40 was found in 30% of hormone-refractory prostate tumors and in 18% of untreated primary breast tumors.
|
10362802 |
1999 |
|
Liver carcinoma
|
0.310 |
Biomarker
|
disease |
BEFREE |
In conclusion, PTK2 and EIF3S3, which, respectively, encode focal adhesion kinase and the p40 subunit of the eukaryotic initiation factor 3, were probable targets within the amplification at 8q23-q24 and may be involved in progression of HCC.
|
14578863 |
2003 |
|
Liver carcinoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
In conclusion, PTK2 and EIF3S3, which, respectively, encode focal adhesion kinase and the p40 subunit of the eukaryotic initiation factor 3, were probable targets within the amplification at 8q23-q24 and may be involved in progression of HCC.
|
14578863 |
2003 |
|
Colorectal Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
|
18372905 |
2008 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Eukaryotic translation initiation factor 3 subunit H (EIF3H) is required for the progression of several types of cancer.
|
30060823 |
2018 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Eukaryotic translation initiation factor 3, subunit H (EIF3H) is a subunit of EIF3, which is involved in mRNA recruitment and ribosomal complex disassembly and is known to be a driver of cell proliferation and survival in cancer.
|
30022709 |
2018 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
These findings uncover a mechanism of translation control that is based on mRNA looping and identify METTL3-eIF3h as a potential therapeutic target for patients with cancer.
|
30232453 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Eukaryotic translation initiation factor 3 subunit H (EIF3H) is required for the progression of several types of cancer.
|
30060823 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Eukaryotic translation initiation factor 3, subunit H (EIF3H) is a subunit of EIF3, which is involved in mRNA recruitment and ribosomal complex disassembly and is known to be a driver of cell proliferation and survival in cancer.
|
30022709 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
These findings uncover a mechanism of translation control that is based on mRNA looping and identify METTL3-eIF3h as a potential therapeutic target for patients with cancer.
|
30232453 |
2018 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The effect of EIF3S3 on growth of NIH 3T3 murine fibroblasts as well as breast (SK-Br-3 and ZR-75-1) and prostate (PC-3 and LNCaP) cancer cell lines was examined by using transfection with inducible pTet-Off system and siRNAs.
|
16652384 |
2006 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
The effect of EIF3S3 on growth of NIH 3T3 murine fibroblasts as well as breast (SK-Br-3 and ZR-75-1) and prostate (PC-3 and LNCaP) cancer cell lines was examined by using transfection with inducible pTet-Off system and siRNAs.
|
16652384 |
2006 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Gain of EIF3S3 was associated with poor cancer-specific survival in incidentally found prostate carcinomas (P = 0.023).
|
11733359 |
2001 |