|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.
|
29326435 |
2019 |
|
Duration of sleep
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways.
|
30804565 |
2019 |
|
Finding of Mean Corpuscular Hemoglobin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.
|
29942086 |
2018 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
|
29844566 |
2018 |
|
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci.
|
28892059 |
2017 |
|
QT interval feature (observable entity)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
|
24952745 |
2014 |
|
Enterovirus Infections
|
0.030 |
Biomarker
|
group |
BEFREE |
Here, we investigated in detail the contribution of a cellular protein, GBF1, in the replication of poliovirus, a representative enterovirus.
|
31375590 |
2019 |
|
Hepatitis C
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Our results provide evidence for an interaction between NS3 and GBF1 and suggest that an alteration of this interaction is detrimental to HCV genome replication.<b>IMPORTANCE</b> Single-stranded, positive-sense RNA viruses rely to a significant extent on host factors to achieve the replication of their genome.
|
30567983 |
2019 |
|
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
Recently, we identified Arf4 and Arf5 (class II Arfs) as host factors required for the replication of hepatitis C virus (HCV), a GBF1-dependent virus.
|
29923822 |
2018 |
|
Enterovirus Infections
|
0.030 |
Biomarker
|
group |
BEFREE |
We also demonstrated with various techniques that the brefeldin-A-sensitive guanidine nucleotide exchange factor, GBF1, was critically important for enterovirus 71 replication.
|
24911624 |
2014 |
|
Enterovirus Infections
|
0.030 |
Biomarker
|
group |
BEFREE |
GBF1/Arf1 and ACBD3 have been proposed to contribute to the recruitment of the essential lipid-modifying enzyme PI4KIIIβ to enterovirus replication organelles.
|
24352456 |
2014 |
|
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
Thus, our results confirm the involvement of GBF1 in HCV replication, and suggest that GBF1 might fulfill another function, in addition to the regulation of the secretory pathway, during HCV replication.
|
24058576 |
2013 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results thus for identified the role of GBF1 in APP trafficking and cleavage, and provide evidence for GBF1 as a possible therapeutic target in AD.
|
31111546 |
2019 |
|
Dwarfism
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results indicate that the deletion in the promoter of <i>PpDXS1</i> isolated from dwarf mutant is sufficient to account for the decrease in <i>PpDXS1</i> transcript level and GBF1 can regulate the <i>PpDXS1</i> gene expression, and subsequently affect accumulation of various isoprenoids throughout the plant.
|
30901811 |
2019 |
|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
GBF1 is such a cellular protein that is required for the replication of several RNA viruses, but its mechanism of action during viral infections is not yet defined.
|
30567983 |
2019 |
|
Hepatitis E
|
0.010 |
Biomarker
|
disease |
BEFREE |
Identification of GBF1 as a cellular factor required for hepatitis E virus RNA replication.
|
29112323 |
2018 |
|
Infection
|
0.010 |
Biomarker
|
group |
LHGDN |
A critical role of a cellular membrane traffic protein in poliovirus RNA replication.
|
19023417 |
2008 |