|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the light of recent data concerning TRAIL receptor distribution, we contribute further by presenting DR5 as the most frequently upregulated DR in colon cancer.
|
19637313 |
2009 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the current study, we established a TRAIL-resistant human colon cancer DLD-1 cell line to clarify the mechanisms of TRAIL-resistance and developed agents to cancel its machinery.
|
26304927 |
2015 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we constructed pcDNA3.1-Egr-1-TRAIL (pEgr.1-TRAIL) recombinant plasmid and evaluated its effect on human colon cancer cell line SW480. pEgr.1-TRAIL transfection combined with radiotherapy caused dramatically elevation of TRAIL expression both in mRNA and protein levels, much lower radiobiological parameters in clonogenic assays, accompanied by remarkably increase in apoptosis ratio.
|
19724854 |
2009 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Urokinase-type plasminogen activator receptor regulates apoptotic sensitivity of colon cancer HCT116 cell line to TRAIL via JNK-p53 pathway.
|
25113506 |
2014 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we found that TRAIL could induce PARP-1 cleavage and apoptosis in colon cancer HCT116 cell, but HT-29 cell was not sensitive to TRAIL.
|
31558316 |
2019 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Evaluation of preventive and therapeutic activity of novel non-steroidal anti-inflammatory drug, CG100649, in colon cancer: Increased expression of TNF-related apoptosis-inducing ligand receptors enhance the apoptotic response to combination treatment with TRAIL.
|
25672292 |
2015 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To investigate the role of p38 MAP kinase activation in the signaling pathway of TRAIL-mediated apoptosis, we compared TRAIL-mediated MAP kinase activation in TRAIL-susceptible human colon cancer cell line DLD1 and TRAIL-resistant DLD1/TRAIL-R cells.
|
14749540 |
2004 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we engineered murine MSCs (mMSCs) to express a secreted form of the TNF-related apoptosis-inducing ligand (TRAIL), which is a potent inducer of apoptosis in tumor cells, and tested these MSCs, termed MSC.sTRAIL, in combination with conventional chemotherapeutic drug treatment in colon cancer models.
|
23429289 |
2013 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Colon cancer (HCT116, SW480), prostate cancer (PC3, LNCaP) and leukemia (K562) cells were treated with STI571 and TRAIL.
|
22462553 |
2012 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we attempted to develop a multimodality approach using chemotherapeutic agent mitomycin C, biologic agent tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo-2L), and mild hyperthermia to treat colon cancer.
|
25156145 |
2014 |
|
Malignant tumor of colon
|
0.400 |
Therapeutic
|
disease |
CTD_human |
17-Allylamino-17-demethoxygeldanamycin overcomes TRAIL resistance in colon cancer cell lines.
|
15993848 |
2005 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Targeted RNA interference of PI3K pathway components sensitizes colon cancer cells to TNF-related apoptosis-inducing ligand (TRAIL).
|
16153452 |
2005 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor associated macrophages protect colon cancer cells from TRAIL-induced apoptosis through IL-1beta-dependent stabilization of Snail in tumor cells.
|
20661477 |
2010 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Subsequent overexpression of TRUNDD in colon cancer cell lines caused a significant delay in killing induced by TRAIL.
|
10933923 |
2000 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Soluble TRAIL gene and actinomycin D synergistically suppressed multiple metastasis of TRAIL-resistant colon cancer in the liver.
|
16478647 |
2007 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study we have tested LUV-TRAIL in several human colon cancer cell lines with different sensitivity to sTRAIL.
|
27725224 |
2016 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
The combination of TRAIL along with agents such as Act D or CHX, which target proteins that prevent cell death, may provide a more effective and less toxic regimen for treatment of resistant colon cancers.
|
11309649 |
2001 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Gene therapy in colon cancer cells with a fiber-modified adenovector expressing the TRAIL gene driven by the hTERT promoter.
|
15517918 |
2004 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we sought to further confirm the antitumor activity of oncolytic virus-armed tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene therapy in xenografts, which derived from the tumors of patients with colon cancer.
|
21183948 |
2011 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Niacin alleviates TRAIL-mediated colon cancer cell death via autophagy flux activation.
|
26517672 |
2016 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
TRAIL is pro-apoptotic on colon cancer cells, while not cytotoxic towards normal healthy cells.
|
26771233 |
2016 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we report that gefitinib and TRAIL in combination produce a potent synergistic effect on TRAIL-sensitive human colon cancer HCT116 cells and an additive effect on TRAIL-resistant HT-29 cells.
|
27629794 |
2016 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the effect of silibinin and TRAIL in an in vitro model of human colon cancer progression, consisting of primary colon tumor cells (SW480) and their derived TRAIL-resistant metastatic cells (SW620).
|
22555452 |
2012 |
|
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines.
|
19352384 |
2009 |
|
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
The in vivo capability of 2-14 to sensitize colon cancer cells to TRAIL-induced apoptosis was evaluated in a syngenic colon cancer model in which CT26-derived grafts were induced in mice.
|
21817114 |
2011 |