TNFSF10, TNF superfamily member 10, 8743

N. diseases: 445; N. variants: 10
Disease: Childhood Leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.070 Biomarker disease BEFREE TRAIL is currently under investigation for the treatment of leukemia. 30257312 2018
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.070 AlteredExpression disease BEFREE BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand (TRAIL) in Philadelphia chromosome-positive leukemia. 22665066 2013
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.070 Biomarker disease BEFREE Here we investigated whether TRAIL targets leukemia-initiating cells. 22408264 2012
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.070 Biomarker disease BEFREE It enhanced cytotoxicity in TRAIL-treated K562 leukemia cells and reduced TRAIL-induced apoptosis in HCT116 and SW480 colon cancer cells, while having no effect on PC3 and LNCaP cells. 22462553 2012
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.070 AlteredExpression disease BEFREE Effective gene-viral therapy of leukemia by a new fiber chimeric oncolytic adenovirus expressing TRAIL: in vitro and in vivo evaluation. 19417152 2009
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.070 AlteredExpression disease BEFREE Expression of the TRAIL receptors in blood mononuclear cells in leukemia. 18158563 2007
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.070 GeneticVariation disease BEFREE In summary, constitutive TRAIL susceptibility differs between leukemia subtypes and does not correlate with mRNA expression levels of the TRAIL receptors R1-R4 as well as constitutive NF-kappa B activation status. 11417478 2001