|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
The high nuclear expression of TRIM24 was correlated with the depth of invasion (P=0.007), tumor-node-metastasis stage (P=0.005), and lymph node metastasis (P=0.027), and shorter overall survival rates (P=0.010) in patients with GC.
|
28454326 |
2017 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Further study indicated that TRIM24 induced cervical cancer cell migration and invasion was through the NF-κB and AKT signaling pathways.
|
28337289 |
2017 |
|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
TRIM24 overexpression was associated with local invasion and advanced grade of bladder cancer.
|
25846736 |
2015 |
|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, depleting TRIM24 expression by small interfering RNA inhibited growth and invasion in lung cell lines.
|
22666376 |
2012 |
|
Malignant neoplasm of prostate
|
0.050 |
Biomarker
|
disease |
BEFREE |
Recently, TRIM24 has been identified to promote androgen receptor signaling and to correlate with an aggressive prostate cancer phenotype.
|
31178279 |
2019 |
|
Malignant neoplasm of prostate
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
TRIM24 is also up-regulated from localized prostate cancer to metastatic castration-resistant prostate cancer (CRPC).
|
30867828 |
2019 |
|
Malignant neoplasm of prostate
|
0.050 |
Biomarker
|
disease |
BEFREE |
Real-time reverse transcription PCR analysis revealed a reciprocal relationship between miR-137 and TRIM24 in prostate cancer cell lines and tissues.
|
31217891 |
2019 |
|
Prostate carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Real-time reverse transcription PCR analysis revealed a reciprocal relationship between miR-137 and TRIM24 in prostate cancer cell lines and tissues.
|
31217891 |
2019 |
|
Prostate carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
TRIM24 is also up-regulated from localized prostate cancer to metastatic castration-resistant prostate cancer (CRPC).
|
30867828 |
2019 |
|
Prostate carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Recently, TRIM24 has been identified to promote androgen receptor signaling and to correlate with an aggressive prostate cancer phenotype.
|
31178279 |
2019 |
|
Malignant neoplasm of prostate
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
TRIM24 and AR coactivated gene signature of SPOP-mutant PCa is similarly activated in human PCa with high TRIM28 expression.
|
30479348 |
2018 |
|
Prostate carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
TRIM24 and AR coactivated gene signature of SPOP-mutant PCa is similarly activated in human PCa with high TRIM28 expression.
|
30479348 |
2018 |
|
Malignant neoplasm of prostate
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Expression of TRIM24 protein increases from primary PC to CRPC, and both TRIM24 protein levels and the AR/TRIM24 gene signature predict disease recurrence.
|
27238081 |
2016 |
|
Prostate carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Expression of TRIM24 protein increases from primary PC to CRPC, and both TRIM24 protein levels and the AR/TRIM24 gene signature predict disease recurrence.
|
27238081 |
2016 |
|
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Tripartite motif-containing protein 24 (TRIM24), recognized as an epigenetic reader for acetylated H3K23 (H3K23ac) via its bromodomain, has been closely involved in tumorigenesis or tumor progression of several cancers.
|
31776034 |
2020 |
|
Squamous cell carcinoma of the head and neck
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we analyzed the expression pattern of TRIM24 in 100 HNSCC tissues and found that TRIM24 was overexpressed in 43/100 HNSCC cases.
|
29862279 |
2018 |
|
Malignant neoplasm of stomach
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In our study, miR-511 was found to be downregulated in GC and an inverse correlation was observed between TRIM24 and miR-511 expression in primary GC tissues and cell lines.
|
28114950 |
2017 |
|
Malignant neoplasm of stomach
|
0.030 |
Biomarker
|
disease |
BEFREE |
Taken together, these data suggested that TRIM24 was a prognostic or potential therapeutic target for patients with GC and was important in the activation of the Wnt/β-catenin pathway during the progression of GC.
|
28454326 |
2017 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, TRIM24 is overexpressed in cervical cancer and regulates malignant cell metastasis, which makes TRIM24 a candidate therapeutic target for cervical cancer.
|
28337289 |
2017 |
|
Stomach Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In our study, miR-511 was found to be downregulated in GC and an inverse correlation was observed between TRIM24 and miR-511 expression in primary GC tissues and cell lines.
|
28114950 |
2017 |
|
Stomach Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Taken together, these data suggested that TRIM24 was a prognostic or potential therapeutic target for patients with GC and was important in the activation of the Wnt/β-catenin pathway during the progression of GC.
|
28454326 |
2017 |
|
Squamous cell carcinoma of the head and neck
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, we identified altered glucose metabolism in the progression of HNSCC and showed that it could be partially attributed to the novel link between GLUT4 and TRIM24.
|
28061796 |
2017 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Immunohistochemistry staining shows that the reduced TRIM24 protein is associated with lymph node metastasis (<i>P</i>=0.024), advance pathological TNM (pTNM) stage (<i>P</i>=0.046) and recurrence/metastasis (<i>P</i>=0.001).
|
27689360 |
2016 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
Collectively, these results identify a role for TRIM24 in breast tumorigenesis through reprogramming of glucose metabolism in HMECs, further supporting TRIM24 as a viable therapeutic target in breast cancer.
|
25065590 |
2015 |
|
Malignant neoplasm of stomach
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
TRIM24 is upregulated in human gastric cancer and promotes gastric cancer cell growth and chemoresistance.
|
25724180 |
2015 |