|
Liver carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Taken together, these data enhance our understanding of HCC development in addition to highlighting TRIM24-regulated AMPK signaling as a potential therapeutic target for HCC treatment.
|
29627320 |
2018 |
|
Liver carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Trim24(dlE1/dlE1) mice have markedly depleted visceral fat and, like Trim24(hep/hep) mice, spontaneously develop hepatic lipid-filled lesions, steatosis, hepatic injury, fibrosis and hepatocellular carcinoma.
|
25281858 |
2015 |
|
Liver carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
These results indicated that TRIM24 plays an important role in the pathogenesis of human HCC.
|
24409330 |
2014 |
|
Liver carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
We further show that deletion of a single retinoic acid receptor alpha (Rara) allele in a Trim24-null background suppresses HCC development and restores wild-type expression of retinoic acid-responsive genes in the liver, thus demonstrating that in this genetic background Rara expresses an oncogenic activity correlating with a dysregulation of the retinoic acid signaling pathway.
|
18026104 |
2007 |
|
Papillary thyroid carcinoma
|
0.310 |
FusionGene
|
disease |
ORPHANET |
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
|
17062879 |
2006 |
|
Papillary thyroid carcinoma
|
0.310 |
FusionGene
|
disease |
ORPHANET |
The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas.
|
10439047 |
1999 |
|
Papillary thyroid carcinoma
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas.
|
10439047 |
1999 |
|
Prostatic Cancer, Castration-Resistant
|
0.300 |
Biomarker
|
disease |
CTD_human |
TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer.
|
27238081 |
2016 |
|
Prostatic Neoplasms, Castration-Resistant
|
0.300 |
Biomarker
|
disease |
CTD_human |
TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer.
|
27238081 |
2016 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Squamous cell carcinoma of lung
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Ovarian Serous Adenocarcinoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Tripartite motif-containing protein 24 (TRIM24), recognized as an epigenetic reader for acetylated H3K23 (H3K23ac) via its bromodomain, has been closely involved in tumorigenesis or tumor progression of several cancers.
|
31776034 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We found that the tumor suppressor miRNA miR-137 silenced signaling in a spectrum of human cancers and selectively targeted tripartite motif-containing 24 (TRIM24) to suppress tumor proliferation.
|
31217891 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
5-(10-) year bRFS rates for TRIM24 negative, low, medium and high expressing tumors are 93.1(93.1)%, 75.4(68.5)%, 54.9(47.5)% and 43.1(32.3)%, respectively.
|
31178279 |
2019 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
SET (also called I2PP2A and TIF-1) is a multi-functional protein that regulates a variety of cell signaling including nucleosome assembly, histone binding, and tumorigenesis.
|
31557212 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Paired blood and tumour DNA samples from patients with anti-TIF1γ-positive CAM and from controls were analysed by whole-exome sequencing for the presence of somatic mutations and loss of heterozygosity (LOH) in their TIF1 genes.
|
29149307 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the present study, TRIM24 was found increased in human HCC clinical samples and positively correlated with HCC tumor grade.
|
29627320 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TRIM24 protein expression was positively correlated with tumor size (P=0.0269), clinical stage (P=0.0061), vital status (P=0.0110) and serum carcinoembryonic antigen levels (P=0.0176).
|
28916426 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tripartite motif-containing 24 (TRIM24) is important in tumor development and progression.
|
28454326 |
2017 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Consequently, TRIM24 functions as a transcriptional co-activator and recruits STAT3, leading to stabilized STAT3-chromatin interactions and subsequent activation of STAT3 downstream signaling, thereby enhancing EGFR-driven tumorigenesis.
|
29129908 |
2017 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Although TRIM24 expression is remarkably upregulated during GC carcinogenesis, the molecular mechanisms underlying TRIM24 dysregulation remain unexplored.
|
28114950 |
2017 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Mechanistic investigations demonstrated that KAT6A acetylates lysine 23 of histone H3 (H3K23), which recruits the nuclear receptor binding protein TRIM24 to activate <i>PIK3CA</i> transcription, thereby enhancing PI3K/AKT signaling and tumorigenesis.
|
29021135 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Knockdown of TRIM24 suppresses cell proliferation, cell cycle progression, clone formation and in vivo tumor development, whereas overexpression of TRIM24 promotes cell growth.
|
24469053 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast, TRIM24 in the mouse is reportedly a liver-specific tumour suppressor.
|
25281858 |
2015 |