|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We found that the tumor suppressor miRNA miR-137 silenced signaling in a spectrum of human cancers and selectively targeted tripartite motif-containing 24 (TRIM24) to suppress tumor proliferation.
|
31217891 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
5-(10-) year bRFS rates for TRIM24 negative, low, medium and high expressing tumors are 93.1(93.1)%, 75.4(68.5)%, 54.9(47.5)% and 43.1(32.3)%, respectively.
|
31178279 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Paired blood and tumour DNA samples from patients with anti-TIF1γ-positive CAM and from controls were analysed by whole-exome sequencing for the presence of somatic mutations and loss of heterozygosity (LOH) in their TIF1 genes.
|
29149307 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the present study, TRIM24 was found increased in human HCC clinical samples and positively correlated with HCC tumor grade.
|
29627320 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TRIM24 protein expression was positively correlated with tumor size (P=0.0269), clinical stage (P=0.0061), vital status (P=0.0110) and serum carcinoembryonic antigen levels (P=0.0176).
|
28916426 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tripartite motif-containing 24 (TRIM24) is important in tumor development and progression.
|
28454326 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Knockdown of TRIM24 suppresses cell proliferation, cell cycle progression, clone formation and in vivo tumor development, whereas overexpression of TRIM24 promotes cell growth.
|
24469053 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast, TRIM24 in the mouse is reportedly a liver-specific tumour suppressor.
|
25281858 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Subcutaneous injection of TRIM24 iHMECs in nude mice led to growth of intermediate to high-grade tumors in 60-70% of mice.
|
25065590 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TRIM24 was originally named transcription intermediary factor 1-alpha (TIF1α), which was associated with cellular proliferation and was an oncogene in tumor development.
|
24409330 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression levels of TRIM24 measured in 91 locally advanced HNSCC tumors were measured by immunohistochemistry and correlated with clinical and pathological parameters.
|
23717505 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In a cohort of 19 tamoxifen-resistant breast tumor samples, there was no significant difference in the level of the RIP140 and TIF-1 and corepressor SMRT mRNA compared with tamoxifen-treated tumors (n = 6) or untreated tumors (n = 21).
|
10589759 |
1999 |