TRIM24, tripartite motif containing 24, 8805

N. diseases: 79; N. variants: 0
Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.330 Biomarker disease BEFREE Taken together, these data enhance our understanding of HCC development in addition to highlighting TRIM24-regulated AMPK signaling as a potential therapeutic target for HCC treatment. 29627320 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.330 Biomarker disease BEFREE Trim24(dlE1/dlE1) mice have markedly depleted visceral fat and, like Trim24(hep/hep) mice, spontaneously develop hepatic lipid-filled lesions, steatosis, hepatic injury, fibrosis and hepatocellular carcinoma. 25281858 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.330 Biomarker disease BEFREE These results indicated that TRIM24 plays an important role in the pathogenesis of human HCC. 24409330 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.330 Biomarker disease CTD_human We further show that deletion of a single retinoic acid receptor alpha (Rara) allele in a Trim24-null background suppresses HCC development and restores wild-type expression of retinoic acid-responsive genes in the liver, thus demonstrating that in this genetic background Rara expresses an oncogenic activity correlating with a dysregulation of the retinoic acid signaling pathway. 18026104 2007