GALR2, galanin receptor 2, 8811

N. diseases: 41; N. variants: 2
Disease: Seizures ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036572
Disease: Seizures
Seizures 		0.020 Biomarker phenotype BEFREE These results are consistent with the previous data showing that GAL2-R knockdown does not affect the number of perforant path stimulations required for initiating status epilepticus but significantly increases the seizure severity during the ongoing status. 30298565 2018
CUI: C0036572
Disease: Seizures
Seizures 		0.020 Biomarker phenotype BEFREE NAX 810-2, a galanin receptor subtype 2 (GalR2)-preferring galanin analog, possesses 15-fold greater affinity for GalR2 over GalR1 and protects against seizures in the mouse 6 Hz, corneal kindling, and Frings audiogenic seizure models. 28098336 2017