CES2, carboxylesterase 2, 8824

N. diseases: 87; N. variants: 1
Disease: Diarrhea ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011991
Disease: Diarrhea
Diarrhea 		0.030 Biomarker phenotype BEFREE In summary, glabridin was a potent and specific inhibitor targeting intracellular CES2A, which could be used as an ideal lead compound to develop more efficacious CES2A inhibitors for modulating the pharmacokinetic behaviors of CES2A-substrate drugs and alleviating irinotecan-induced diarrhea. 31260759 2019
CUI: C0011991
Disease: Diarrhea
Diarrhea 		0.030 Biomarker phenotype BEFREE Co-administration with CES2 inhibitors may ameliorate CPT-11 associated lifethreatening diarrhea or improve the half-lives of CES2-substrate drugs. 29210644 2018
CUI: C0011991
Disease: Diarrhea
Diarrhea 		0.030 GeneticVariation phenotype BEFREE The presence of two polymorphisms (CDD 943insC and CES 2 Exon3 6046 G/A) were associated with a non-statistically significant higher incidence of grade 3 hand-foot syndrome (HFS) (p=0.07) and grade 3-4 diarrhoea (p=0.09), respectively. 18473752 2008