|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This multifunctionalized theranostic nanodevice based on orthogonal conjugation strategies could be a good candidate for the treatment and monitoring of Nrp-1 overexpressing tumors.
|
31676374 |
2020 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Antitumor activity of ER-472 in xenografts correlated to tumor NRP1 expression.
|
31208428 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It causes microtubule depolymerization and significant tumor regression in Nrp-1 overexpressed mice melanoma model.
|
31009223 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Unlike the majority of nanoparticles that depend solely on enhanced permeability and retention (EPR) for their transport into the tumor, our peptide-based nanoplex has a potential advantage in that its uptake primarily depends on neuropilin-1 receptor targeting.
|
30954222 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Anti-NRP-1 mAb could guide tTF to the surface of tumor vascular endothelial cells and lead to subsequent vascular embolization.
|
30807552 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Several therapeutic anticancer therapies focus on inhibition of Nrp1 to restrict tumor growth, and so knowledge of how Nrp1 blockade may affect the CD8 T cell response will provide a better understanding of treatment consequences.<b>IMPORTANCE</b> CD8 T cell responses are critical to control both virus infections and tumors.
|
31118303 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The iRGD domain exhibits tumor-targeting and tumor-penetrating activities by specifically binding to the neuropilin-1 receptor.
|
30592418 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Construction of novel procoagulant protein targeting neuropilin-1 on tumour vasculature for tumour embolization therapy.
|
30628471 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Noteworthy, current data support a promoting role for Semaphorin 4D and Neuropilin-1 in these tumors, while Semaphorin 3A seems to consistently act as oncosuppressor in leukemias and multiple myeloma.
|
31143707 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The role of the hypoxia-Nrp-1 axis in the activation of M2-like tumor-associated macrophages in the tumor microenvironment of cervical cancer.
|
30362630 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this system, anti‑NRP‑1‑mAb located tTF to the tumor vascular endothelial cell surface and induced vascular embolization.
|
31432158 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor xenografts model was used to evaluate the effect of NRP-1 on the tumor growth.
|
31114235 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Western blot, qRT-PCR, immunofluorescence, cytometric bead array and flow cytometry were used to investigate the effect of the tumor microenvironment in NRP1-induced lung cancer cell radiation resistance.
|
31417646 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Anti-Nrp-1 neutralising antibodies enhance the migration and cytotoxicity of Nrp-1<sup>+</sup>PD-1<sup>hi</sup> CD8<sup>+</sup> TIL ex vivo, while in vivo immunotherapeutic blockade of Nrp-1 synergises with anti-PD-1 to enhance CD8<sup>+</sup> T-cell proliferation, cytotoxicity and tumour control.
|
31350404 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nrp1 also helps migrate thymus-derived regulatory T cells to vascular endothelial growth factor (VEGF)-producing tumors.
|
31740486 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Consequently, these advantages facilitate the transfer of CRGDK fragments from integrins to neuropilin-1 and consequently deeper penetration into the tumor.
|
31346334 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent evidence suggests that NRP1 affects tumour cell viability via the epidermal growth factor receptor (EGFR) and Erb-B2 receptor tyrosine kinase 2 (ErbB2) signalling pathways in venous endothelial cells and in multiple cancer cells.
|
30811684 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Administration of the NRP-body to pancreatic cancer model mice increased tumor tissue infiltration of transferred NK cells and reduced the tumor burden compared with that in controls.
|
30514792 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SIGNIFICANCE: This work reveals that the interaction between fragmented chromogranin A and neuropilin-1 is required for tumor growth and represents a novel potential therapeutic target.
|
30796053 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mice with Treg cell-restricted Neuropilin-1 deficiency show tumor resistance while maintaining peripheral immune homeostasis, thereby providing a controlled system to interrogate the impact of intratumoral Treg cells on the TME.
|
31350177 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Xenograft tumor models were established to assess the effects of NRP-1 depletion on tumorigenesis and liver metastasis, and therapeutic effects of miR-141 on tumor growth.
|
31572065 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The improved delivery of coadministered NPs and antibodies to tumors suggests that the coadministration with APPA self-assembled peptosomes could be a valuable approach for advancing αvβ3 and NRP1 positive tumors diagnosis and therapy.
|
31060320 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Because of CRGDK-mediated targeting to overexpressed neuropilin-1 receptors on tumor vessels and tumor cells, PDNPs released from PDNPs-gel can effectively penetrate into tumor tissues, specifically enter tumor cells and finally realize intracellular acid-triggered drug release.
|
31070356 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Widespread expression of NRP-1 in normal tissues may affect anti-NRP-1 antibody tumor uptake.
|
31692439 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The aim of the present study was to determine whether the cell surface protein neuropilin 1 (NRP1) can be used as a biomarker of stem-like cells in lung cancer tumors.
|
29138851 |
2018 |