NRP1, neuropilin 1, 8829

N. diseases: 246; N. variants: 13
Disease: Kidney Failure ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035078
Disease: Kidney Failure
Kidney Failure 		0.010 GeneticVariation disease BEFREE Here we show that Nrp1 is highly expressed by mesangial cells and that genetic deletion of the <i>Nrp1</i> gene from PDGF receptor-β<sup>+</sup> mesangial cells results in proteinuric disease and glomerulosclerosis, leading to renal failure and death within 6 wk of age in mice. 28835419 2017