NRP1, neuropilin 1, 8829

N. diseases: 246; N. variants: 13
Disease: Glomerulosclerosis (disorder) ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0178664
Disease: Glomerulosclerosis (disorder)
Glomerulosclerosis (disorder) 		0.020 AlteredExpression disease BEFREE The transmembrane receptor neuropilin-1 (NRP-1) is highly expressed by mesangial cells and its genetic deletion results in proteinuric disease and glomerulosclerosis. 31533337 2019
CUI: C0178664
Disease: Glomerulosclerosis (disorder)
Glomerulosclerosis (disorder) 		0.020 Biomarker disease BEFREE Here we show that Nrp1 is highly expressed by mesangial cells and that genetic deletion of the <i>Nrp1</i> gene from PDGF receptor-β<sup>+</sup> mesangial cells results in proteinuric disease and glomerulosclerosis, leading to renal failure and death within 6 wk of age in mice. 28835419 2017