<b>Conclusion</b>: Our results verified that NRP1, inflammatory factors, chemokines and related signaling pathways, which affect the transformation of related cell components and thus lung cancer cell immune tolerance and migratory ability, all play an important role in radiation resistance.
Inhibition of NRP1 expression by shRNA in both pancreatic and lung cancer cells containing dominant active KRAS <sup>mt</sup> caused increased cell viability and tumor growth.
Two receptors, neuropilin 1 (NP1) and neuropilin 2 (NP2), bind class 3 semaphorins, axon guidance molecules including SEMA3F, the gene for which was isolated from a 3p21.3 deletion in lung cancer.