CCN4, cellular communication network factor 4, 8840

N. diseases: 114; N. variants: 17
Disease: Non-alcoholic Fatty Liver Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease 		0.020 AlteredExpression disease BEFREE We demonstrated that higher proNT levels are significantly associated with greater macrophages infiltration, HIF-1#, WISP-1, and UNC5B expression in VAT (all <i>p</i> < 0.01) due to the diagnosis of T2D and NAFLD. 29690638 2018
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease 		0.020 Biomarker disease BEFREE These results indicate that WISP1 contributes to hepatic steatosis and skeletal muscle insulin resistance through a TLR4-activated inflammation/JNK signaling pathway and could be a useful therapeutic target for treatment of non-alcoholic fatty liver disease and type 2 diabetes. 29319180 2018