HDAC3, histone deacetylase 3, 8841

N. diseases: 179; N. variants: 5
Disease: Malignant neoplasm of liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.040 Biomarker disease BEFREE HDAC3 Deficiency Promotes Liver Cancer through a Defect in H3K9ac/H3K9me3 Transition. 31097476 2019
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.040 AlteredExpression disease BEFREE Inhibition of HDAC3 expression reduced liver cancer cells growth and inhibited xenograft tumor growth. 29540666 2018
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.040 AlteredExpression disease BEFREE Overexpression of HDAC3 was associated with poor outcome of liver cancer. 23879963 2013
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.040 AlteredExpression disease BEFREE Whereas HDAC3 expression was downregulated in only a small number of human liver cancers, the mRNA levels of the HDAC3 cofactor NCOR1 were reduced in one-third of these cases. siRNA targeting of NCOR1 and SMRT (NCOR2) increased H4K5ac and caused DNA damage, indicating that the HDAC3/NCOR/SMRT axis is critical for maintaining chromatin structure and genomic stability. 21075309 2010