Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD133-overexpressing U251-CD133 and U251-mock glioma cells were constructed.
|
30891998 |
2019 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Notch1 and CXCR4 were both upregulated in GICs, compared to Notch1 positive glioma cells comprised a large proportion in the CD133+ glioma cell spheres, CXCR4 positive glioma cells which usually expressed Notch1 both and dispersed in the periphery of the sphere, only represent a small subset of CD133+ glioma cell spheres.
|
31382985 |
2019 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The majority of glioma stem cells (GSCs) expressing CD133 were also CD146-positive.
|
31147892 |
2019 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MTAP deficiency promotes glioma stem-like cell (GSC) formation with increased expression of <i>PROM1</i>/CD133 and enhanced tumorigenicity of GBM cells and is associated with poor prognosis in patients with GBM.
|
31040154 |
2019 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, a low-density lipoprotein receptor-related protein and a RNA aptamer bound CD133 were used as dual-targeting ligands to prepare dual-modified cationic liposomes (DP-CLPs) loaded with survivin siRNA and paclitaxel (DP-CLPs-PTX-siRNA) for actively targeting imaging and treating CD133<sup>+</sup> glioma stem cells after passing through the blood-brain barrier.
|
30269613 |
2018 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of miR-487b in a pediatric glioma cell line (KNS42) using lentiviral vectors led to a decrease in colony formation in soft agar (30%) (P<0.05), and decreased expression of known predicted targets PROM1 and Nestin (but not WNT5A). miR-487b overexpression had no significant effect on cell growth, proliferation, sensitivity to temozolomide, migration, or invasion.
|
27739438 |
2017 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Analysis of glioma samples revealed that CD133 expression is negatively associated with miR-200b.
|
28599471 |
2017 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Investigation of stemness-related CD133 and cMyc in human samples and rat xenografts exhibited a reciprocal relationship between Cx30 and IGF-1R in the low and high grades (HG) of glioma.
|
28875331 |
2017 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We previously showed that hypoxia promotes the preferential expansion and maintenance of CD133 positive human glioma stem cells (GSC) in a hypoxia inducible factor 1 alpha (HIF-1α)-dependent mechanism.
|
28410215 |
2017 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found higher NEAT1 RNA expression in CD133+ human glioma primary culture stem cells and CD133+ U87 cells via RT-PCR.
|
27878295 |
2017 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We also observed that MET associated with TMZ was able to reduce the expression of glioma stem cells (GSC) marker CD90 particularly in T98G cells but not that of CD133.
|
29348889 |
2017 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we showed that low-level expression of LIM2 in CD133-high glioma was associated with poorer survival, suggesting that LIM2 could be a therapeutic target for glioma expressing a high level of CD133.
|
28055976 |
2017 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest TLR4 signaling is a factor in CD133+ CSC immune evasion, and thus disruption of TLR4 signaling is a potential therapeutic strategy in glioma.
|
28881826 |
2017 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeting effect of microRNA on CD133 and its impact analysis on proliferation and invasion of glioma cells.
|
28362995 |
2017 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These self-assemblies were observed to be selectively toxic to glioma cells and CD133-positive glioma stem like cells population.
|
28947963 |
2017 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, we analysed membrane bound Hsp70 levels in primary and secondary gliomas of different grades and on isolated glioma subpopulations (endothelial cells, CD133-positive cells, primary cultures) by immunohistochemistry and flow cytometry using cmHsp70.1 mAb.
|
28849427 |
2017 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Phosphoribosylpyrophosphate Synthetase 1 Knockdown Suppresses Tumor Formation of Glioma CD133+ Cells Through Upregulating Cell Apoptosis.
|
27343059 |
2016 |
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Immunohistochemistry with stem cell markers, CD133 and EGFRvIII are used to demonstrate that the IDH1 mutant glioma shows limited dependence on cancer stem cells and it shows marked apoptotic signals in TUNEL assay to regulate abnormal cells.
|
27608896 |
2016 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, CD133+ human glioma stem cells were isolated and cultured.
|
27277755 |
2016 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that CD133 overexpression in BTSCs due to P2 hypomethylation underlies glioma recurrence, which may provide insight into the mechanism of glioma recurrence and provide a basis for novel therapies for glioma treatment.
|
27374817 |
2016 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry and flow cytometry analysis of 12 tumor samples obtained from patients with high grade gliomas revealed that a considerable population (2-19%) of cells in all malignant gliomas expressed IL-17RA, with remarkable co-expression of the glioma stem cell (GSC) markers CD133, Nestin, and Sox2.
|
26755664 |
2016 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, no correlation between CD133 protein expression and CD133 promoter methylation status was observed (Kw = -0.165).CD133 promoter methylation status in glioma is closely correlated with patient survival, which suggest CD133 promoter methylaiton pattern is a promising tool for diagnostic purposes.
|
26757925 |
2016 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD133 positive (CD133+) glioma cancer stem-like cells (GCSCs) markedly promote drug resistance and exhibit increased DNA damage repair capability; thus they have a key role in determining tumor chemosensitivity.
|
25823028 |
2016 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To better understand the role of miR-21 in glioma angiogenesis and to characterize miR-21-positive tumor cells, we systematically stained consecutive serial sections from ten astrocytomas for miR-21, hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF), phosphatase and tensin homolog (PTEN), octamer-binding transcription factor 4 (Oct4), sex-determining region Y box 2 (Sox2) and CD133.
|
26701969 |
2016 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we report that CD133 expression enhances glioma cell tolerance of a nutrient-deprived microenvironment.
|
27780926 |
2016 |